Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies

Table 4 Clinical relevance of the IL-10 promoter polymorphisms in patients with major trauma

Genotypes	N	Age (years)	Gender (M/F)	ISS	Sepsis(%)	MOD score	Cytokine (pg/ml)
-1082
AA	224	38.6 ± 14.1	177/47	25.6 ± 8.5	51.3	4.4 ± 2.7	62.0 ± 19.8
AG	73	37.3 ± 13.5	62/11	26.3 ± 7.5	38.4	5.4 ± 2.8	73.9 ± 21.3
GG	11	35.9 ± 20.3	7/4	27.2 ± 10.6	36.4	4.1 ± 2.9	86.0 ± 18.8
-819					a1	b1	a2, b2, c1
TT	157	37.6 ± 13.7	120/37	25.6 ± 8.8	46.5	4.6 ± 2.6	56.2 ± 17.8
TC	122	39.6 ± 14.6	100/22	25.9 ± 8.1	50.8	4.7 ± 2.8	59.9 ± 20.2
CC	29	35.7 ± 15.1	26/3	27.1 ± 7.9	41.4	4.4 ± 2.9	62.4 ± 19.5
-592
AA	141	38.2 ± 14.6	116/25	25.1 ± 7.9	46.1	4.5 ± 2.1	52.9 ± 16.0
AC	123	38.0 ± 13.2	98/25	27.1 ± 9.0	51.2	5.1 ± 3.0	66.8 ± 19.6
CC	43	36.8 ± 16.0	31/12	24.8 ± 8.0	44.2	4.1 ± 2.7	59.8 ± 13.1
							a3, c2

a: dominant effect (variant homozygotes +heterozygotes vs. wild homozygotes) as analyzed by ANCOVA, ^a1P = 0.038, ^a2P = 0.005, ^a3P = 0.001.
b: recessive effect (variant homozygotes vs. heterozygotes + wild homozygotes) as analyzed by ANCOVA, ^b1P = 0.088, ^b2P = 0.083.
c: allele dose effect as analyzed by linear regression analysis, ^c1P = 0.003, ^c2P = 0.037.
ANCOVA = analysis of covariance; F = female; ISS = Injury Severity Score; M = male; MOD = multiple organ dysfunction.

ISSN: 1364-8535