Effect of fluid resuscitation on mortality and organ function in experimental sepsis models

Table 3 Respiratory parameters

Variable	Group	N	Baseline	3 hours	6 hours	12 hours	End	Interactions	P
Dynamic compliance								Time effect:	0.001
	C 10 ml/kg	8	28 ± 6	25 ± 8	26 ± 7	25 ± 8	17 ± 5
	C 20 ml/kg	8	30 ± 7	25 ± 8	26 ± 6	21 ± 5	14 ± 5
	E 10 ml/kg	7	31 ± 7	27 ± 5	28 ± 6	24 ± 5	18 ± 4
	E 20 ml/kg	8	32 ± 3	25 ± 3	24 ± 3	22 ± 5	22 ± 5
	P 10 ml/kg	8	28 ± 2	24 ± 6	20 ± 3	20 ± 2	15 ± 2
	P 20 ml/kg	8	32 ± 8	25 ± 6	21 ± 3	18 ± 2	14 ± 6
Plateau pressure (cmH₂O)								Time × volume effect:	0.043
	C 10 ml/kg	8	18 ± 2	19 ± 2	20 ± 3	19 ± 4	24 ± 4
	C 20 ml/kg	8	18 ± 2	20 ± 2	20 ± 2	22 ± 4	28 ± 8
	E 10 ml/kg	7	16 ± 3	18 ± 4	18 ± 4	17 ± 4	22 ± 6	ANOVArm moderate-volume:	0.001
	E 20 ml/kg	7	15 ± 5	19 ± 7	21 ± 6	18 ± 6	21 ± 7
	P 10 ml/kg	8	17 ± 3	19 ± 3	20 ± 4	22 ± 2	24 ± 5
	P 20 ml/kg	7	16 ± 4	19 ± 6	22 ± 5	22 ± 6	28 ± 6	ANOVArm high-volume:	0.001
Oxygenation index (mmHg/%)								Time × model effect:	0.026
	C 10 ml/kg	8	434 ± 67	394 ± 92	384 ± 97	346 ± 67	212 ± 97	ANOVArm C:	0.001
	C 20 ml/kg	8	456 ± 48	412 ± 80	424 ± 48	347 ± 106	236 ± 122
	E 10 ml/kg	7	477 ± 33	418 ± 44	401 ± 57	352 ± 101	208 ± 116	ANOVArm E:	0.001
	E 20 ml/kg	7	447 ± 44	313 ± 88	291 ± 102	252 ± 110	170 ± 139
	P 10 ml/kg	8	449 ± 29	356 ± 54	300 ± 69	317 ± 99	217 ± 106	ANOVArm P:	0.001
	P 20 ml/kg	8	412 ± 61	292 ± 104	247 ± 74	193 ± 112	63 ± 12

Values are mean ± standard deviation. C = controls; E = endotoxin; P = peritonitis

ISSN: 1364-8535