Skip to main content

Table 2 Filling pressures, mixed venous oxygen saturation and arterial lactate concentrations

From: Effect of fluid resuscitation on mortality and organ function in experimental sepsis models

Variable

Group

N

Baseline

3 hours

6 hours

12 hours

End

Interactions

P

Central venous pressure (mmHg)

         
 

C 10 ml/kg

8

4 ± 2

4 ± 2

5 ± 2

5 ± 1

7 ± 2

ANOVArm moderate-volume:

0.001

 

C 20 ml/kg

8

4 ± 2

6 ± 2

5 ± 2

7 ± 4

10 ± 5

ANOVArm C:

0.001

 

E 10 ml/kg

7

4 ± 2

4 ± 2

5 ± 2

5 ± 2

6 ± 3

ANOVArm E:

0.001

 

E 20 ml/kg

8

3 ± 2

6 ± 3

7 ± 3

7 ± 2

9 ± 1

  
 

P 10 ml/kg

8

3 ± 2

3 ± 1

4 ± 1

6 ± 2

7 ± 2

ANOVArm P:

0.001

 

P 20 ml/kg

8

5 ± 3

6 ± 3

8 ± 4

10 ± 3

14 ± 3

ANOVArm high-volume:

0.001

Pulmonary artery occlusion pressure (mmHg)

         
 

C 10 ml/kg

8

4 ± 2

5 ± 2

5 ± 2

5 ± 2

8 ± 2

ANOVArm:

0.001

 

C 20 ml/kg

8

5 ± 3

6 ± 3

6 ± 2

7 ± 4

10 ± 5

ANOVArm:

0.013

 

E 10 ml/kg

7

5 ± 1

5 ± 2

5 ± 2

5 ± 2

7 ± 4

ANOVArm:

0.10

 

E 20 ml/kg

7

5 ± 3

9 ± 5

7 ± 4

8 ± 5

10 ± 3

ANOVArm:

0.018

 

P 10 ml/kg

8

4 ± 1

4 ± 1

5 ± 2

6 ± 2

8 ± 2

ANOVArm:

0.001

 

P 20 ml/kg

7

7 ± 2

7 ± 2

8 ± 3

10 ± 2

17 ± 8

ANOVArm:

0.008

Mixed venous saturation (%)

       

Time × model effect:

0.009

 

C 10 ml/kg

8

55 ± 6

54 ± 11

55 ± 1

55 ± 8

57 ± 7

  
 

C 20 ml/kg

8

49 ± 7

59 ± 5

59 ± 4

60 ± 1

55 ± 18

  
 

E 10 ml/kg

7

49 ± 6

51 ± 5

55 ± 6

57 ± 3

55 ± 8

ANOVArm E:

0.013

 

E 20 ml/kg

7

49 ± 5

49 ± 11

60 ± 8

66 ± 2

56 ± 11

  
 

P 10 ml/kg

8

53 ± 7

59 ± 4

58 ± 7

55 ± 6

47 ± 13

ANOVArm P:

0.008

 

P 20 ml/kg

7

46 ± 1

57 ± 12

56 ± 14

57 ± 9

43 ± 24

  

Arterial lactate (mmol/l)

       

Time × model effect:

0.046

 

C 10 ml/kg

8

0.6 ± 0.2

0.5 ± 0.2

0.7 ± 0.5

0.6 ± 0.1

0.7 ± 0.2

  
 

C 20 ml/kg

8

0.6 ± 0.1

0.6 ± 0.2

0.6 ± 0.1

0.6 ± 0.1

1.0 ± 1.0

  
 

E 10 ml/kg

7

0.7 ± 0.1

1.2 ± 0.7

0.9 ± 0.4

0.8 ± 0.3

0.9 ± 0.5

ANOVArm E:

0.04

 

E 20 ml/kg

8

0.7 ± 0.1

1.0 ± 0.3

0.9 ± 0.3

1.0 ± 0.2

1.0 ± 0.3

  
 

P 10 ml/kg

8

0.6 ± 0.2

1.4 ± 0.6

1.5 ± 0.6

1.1 ± 0.4

1.5 ± 0.6

ANOVArm P:

0.001

 

P 20 ml/kg

8

0.8 ± 0.6

1.1 ± 0.6

1.1 ± 0.6

1.1 ± 0.3

1.4 ± 0.6

  
  1. Values are mean ± standard deviation. C = controls; E = endotoxin; P = peritonitis
Back to article page

Critical Care

ISSN: 1364-8535