Table 3 Risk factors of bleeding complications in children with CRRT
Bleeding | No bleeding | P | |||
|---|---|---|---|---|---|
Mean | SD | Mean | SD | ||
Age (months) | 64.2 | 70.8 | 49.5 | 62.3 | 0.385 |
Weight (kg) | 22.7 | 22.0 | 16.6 | 17.5 | 0.310 |
PRISM score | 15.0 | 7.0 | 14.7 | 8.5 | 0.643 |
PIM score | -2.1 | 0.9 | -2.0 | 1.5 | 0.929 |
PELOD score | 18.1 | 9.2 | 17.5 | 8.1 | 0.402 |
Number of failed organs | 3.3 | 1.1 | 2.9 | 1.1 | 0.189 |
Lactic acid (mmol/L) | 4.3 | 5.4 | 2.9 | 3.4 | 0.530 |
Arterial pH | 7.31 | 0.1 | 7.31 | 0.1 | 0.906 |
MAP (mmHg) | 56.2 | 22.7 | 62.0 | 18.2 | 0.211 |
Dose of adrenaline (μg/kg/min) | 0.5 | 0.6 | 0.5 | 1.2 | 0.409 |
Dose of dopamine (μg/kg/min) | 10.9 | 8.2 | 8.8 | 6.3 | 0.295 |
Initial creatinine (mg/dL) | 1.2 | 0.8 | 1.5 | 1.4 | 0.956 |
Initial urea (mg/dL) | 93.8 | 68.9 | 82.9 | 59.0 | 0.475 |
ALT (UI/L) | 174.7 | 171.0 | 209.5 | 776.3 | 0.355 |
Billirubine (mg/dL) | 3.1 | 4.0 | 1.5 | 1.4 | 0.218 |
Initial platelet (inicial) | 150.944 | 119.341 | 177.289 | 170.637 | 0.821 |
Platelet after 24 hours of CRRT | 89.000 | 72.960 | 122.068 | 111.964 | 0.254 |
Platelet after 48 hours of CRRT | 93.000 | 76.183 | 105.589 | 99.070 | 0.657 |
Maximum dose of heparin (UI/kg/h) | 14.7 | 13.1 | 15.2 | 10.3 | 0.351 |
Ultrafiltration rate (mL/kg/h) | 43.6 | 34.4 | 37.3 | 25.3 | 0.751 |
Circuit lifespan (h) | 47.5 | 61.5 | 41.9 | 36.9 | 0.638 |
Bleeding Number % | Bleeding Number % | ||||
Age | <12 m | >12 m | |||
9 | 11.8 | 9 | 9.4 | 0.600 | |
Sex | Male | Female | |||
9 | 8.7 | 9 | 13 | 0.366 | |
Weight | <10 kg | >10 kg | |||
9 | 10 | 9 | 11 | 0.835 | |
Diagnoses | Cardiopathies | Rest of diagnoses | |||
10 | 10.5 | 8 | 10.4 | 0.977 | |
Mechanical ventilation | Yes | No | |||
17 | 11.7 | 1 | 3.7 | 0.211 | |
Vasoactive drugs | Yes | No | |||
15 | 11 | 3 | 8.3 | 0.638 | |
Initial MAP | < 55 mmHg | > 55 mmHg | |||
11 | 17.5 | 7 | 6.6 | 0.034 | |
Initial hypotension | Sí | No | |||
10 | 14.3 | 8 | 8.3 | 0.241 | |
Dose of adrenaline | >0.6 μg/kg/min | >0.6 μg/kg/min | |||
5 | 14.7 | 13 | 11 | 0.561 | |
Platelet | <50.000 | >50.000 | |||
6 | 20 | 12 | 10.3 | 0.152 | |
Platelet transfusion | Sí | No | |||
14 | 18.9 | 4 | 4.1 | 0.002 | |
CRRT technique | Hemofiltration | Hemodiafiltration | |||
3 | 6.7 | 15 | 11.8 | 0.333 | |
Filter surface | <0.3 m2 | >0.3 m2 | |||
9 | 14.3 | 9 | 14.7 | 0.937 | |
Maximum dose of heparin | >10 U/kg/h | <10 U/kg/h | |||
7 | 8.4 | 11 | 12.4 | 0.401 | |
Mortality | Yes | No | |||
10 | 55.6% | 8 | 33.8% | 0.068 | |