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Figure 2 | Critical Care

Figure 2

From: Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion

Figure 2

High plasma levels of HMGB1 are associated with the release of inflammatory mediators and markers of endothelial cell and complement activation in trauma patients. Blood samples were obtained from 168 consecutive major trauma patients immediately upon admission to the hospital. (a to d) Plasma levels of high mobility group box nuclear protein 1 (HMGB1) are associated with increased plasma levels of IL-6, TNF-α, Von Willebrand Factor (vWF) and angiopoietin-2 (Ang-2). (e) High plasma levels of HMGB1 are associated with increased complement activity as indicated by elevated soluble C5b-9 plasma levels that are generated during the late phase of complement activation. Data are presented in quartiles, *P ≤ 0.05 based on test for rank and trend.

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Critical Care

ISSN: 1364-8535