Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: results from an observational study

Table 2 Flow-cytometric data of patients with sepsis due to VAP and sepsis caused by other nosocomial infections.

	VAP	Other infections	P
CD3(+)/CD4(+)	208.52 (192)	280.68 (508.7)	0.034
CD3(+)/CD8(+)	114.8 (123.26)	102.49 (244.7)	0.787
CD3(+)/CD(16+56)(+)	18.09 (34.41)	15.11 (49.49)	0.940
*Natural killer cells	26.98 (62.94)	39.61 (45.22)	0.463
CD19(+)	28.00 (70.00)	37.93 (33.82)	0.219
Annexin(+)/CD4(+)/PI(-)	3.16 (4.48)	2.33 (7.64)	0.944
Annexin(+)/CD8(+)/PI(-)	3.74 (8,71)	6.47 (15.71)	0.269
Annexin(+)/PI(-) of isolated monocytes	20.62 (28.11)	12.19 (22.98)	0.007

*Natural killer cells were defined as CD3(-)/CD(16+56)(+). Values are expressed as median (IQR) absolute numbers for CD3(+)/CD4(+), CD3(+)/CD8(+), CD3(+)/CD(16+56)(+), natural killer and CD19(+) cells and as median (interquartile range) percentages for Annexin(+)/CD4(+)/PI(-), Annexin(+)/CD8(+)/PI(-) and Annexin(+)/PI(-) of isolated monocytes. VAP = ventilator-associated pneumonia.

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