Increased cardiac index due to terbutaline treatment aggravates capillary-alveolar macromolecular leakage in oleic acid lung injury in dogs

Table 1 Hemodynamic and gas exchange data in groups 3 and 4

Mean ± SEM	Steady state 30 - 75 min	Peak 75 - 120 min	Early recovery 120 - 180 min	Late recovery 180 - 240 min
ABP (mmHg)
Group 3	95.4 ± 4.3	75.3 ± 9.0	84.7 ± 7.8	102.8 ± 3.3
Group 4	93.0 ± 8.1	82.5 ± 4.6	93.8 ± 8.3	91.3 ± 3.1
Cardiac index (L/min/kg)
Group 3	0.16 ± 0.01	0.09 ± 0.01	0.10 ± 0.01	0.12 ± 0.01
Group 4	0.14 ± 0.01	0.13 ± 0.01	0.13 ± 0.09	0.24 ± 0.02 *
PAP (mmHg)
Group 3	17.1 ± 1.2	13.2 ± 1.3	15.2 ± 1.3	18.5 ± 1.8
Group 4	17.9 ± 1.9	18.4 ± 1.4	18.2 ± 1.5	24.2 ± 0.9 *
Pcap (mmHg)
Group 3	10.5 ± 1.5	10.5 ± 1.5	9.7 ± 1.1	10.3 ± 0.5
Group 4	12.6 ± 1.6	14.0 ± 1.1	13.2 ± 1.3	15.6 ± 1.2
PAOP (mmHg)
Group 3	6.9 ± 0.6	6.3 ± 0.9	6.0 ± 1.0	6.0 ± 0.4
Group 4	9.4 ± 1.5	9.3 ± 1.0	9.0 ± 1.7	10.0 ± 0.7
PVR (mmHg/L/min/kg)
Group 3	63.7 ± 7.6	76.8 ± 5.5	92.0 ± 10.2	104.1 ± 12.6
Group 4	60.7 ± 11.5	70.1 ± 15.1	71.3 ± 12.1	58.9 ± 11.5 *
PaO2/FiO2 (kPa)
Group 3	36.2 ± 0.7	14.5 ± 4.4	10.5 ± 2.9	10.8 ± 3.7
Group 4	27.9 ± 2.0	16.6 ± 2.7	15.3 ± 3.2	15.2 ± 3.1

ABP = systemic arterial blood pressure; FiO2 = fraction of inspired oxygen; PaO2 = partial pressure of oxygen in arterial blood; PAOP = pulmonary arterial occlusion pressure; PAP = pulmonary arterial blood pressure; Pcap = pulmonary capillary pressure; PVR = total pulmonary vascular resistances; SEM = standard error of the mean.
Group 3 = OA injury without terbutaline (n = 7); Group 4 = OA + terbutaline (n = 6); * P < 0.05 early recovery versus late recovery in group 4 (OA + terbutaline) (intra-group comparison by analysis of variance and the post-hoc test of Tukey-Kramer).

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