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Table 3 Comparison of MMP-9, MMP-10, TIMP-1, TNF-α, and IL-10 serum levels between surviving and nonsurviving sepsis patients (median and 25 th to 75 th percentiles are shown)

From: Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis

 

Survivors

(n = 125)

Nonsurvivors

(n = 67)

P

MMP-9: median ng/ml (percentile 25-75)

784 (371-1222)

554 (240-1044)

0.037

TIMP-1: median ng/ml (percentile 25-75)

573 (422-724)

797 (499-1,012)

<0.001

MMP-10: median pg/ml (percentile 25-75)

1,850 (1,187-2,956)

2,284 (1,262-4,329)

0.09

MMP-9/TIMP-1 ratio: median (percentile 25-75)

1.39 (0.63-2.42)

0.82 (0.28-1.66)

0.003

MMP-10/TIMP-1 ratio: median (percentile 25-75)

3.12 (2.14-5.06)

2.97 (1.72-5.21)

0.46

TNF-α: median pg/ml (percentile 25-75)

30 (19-51)

34 (18-70)

0.38

IL-10: median pg/ml (percentile 25-75)

10 (5-37)

36 (9-103)

<0.001

TNF-α/IL-10 ratio: median (percentile 25-75)

2.49 (1.39-3.92)

1.20 (0.47-2.38)

<0.001

  1. IL = interleukin; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase; TNF = tumor necrosis factor.