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Table 2 Univariate analysis of variables associated with candidemia

From: Candidemia on presentation to the hospital: development and validation of a risk score

  Derivation cohort (n = 64,019) Validation cohort (n = 24,685)
Variable Number of candidemia/Number of cases in the row (%) P Value Number of candidemia/Number of cases in the row (%) P Value
Candidemia cases/Total cases 738/64,019 (1.2)   321/24,685 (1.3) 0.0697
Demographics     
   Age < 65 years 331/19,523 (1.7) < 0.0001 137/8403 (1.6) 0.0010
   Men 377/29,845 (1.3) 0.0158 170/12,090 (1.4) 0.1508
Laboratory findings     
   Albumin ≤ 1.8 g/dL 83/2704 (3.1) < 0.0001 40/1278 (3.1) < 0.0001
   Albumin 1.9--2.2 g/dL 75/3800 (2.0) < 0.0001 45/1757 (2.6) < 0.0001
   Arterial pH ≤ 7.36 130/5913 (2.2) < 0.0001 61/2684 (2.3) < 0.0001
   Potassium > 5.6 mEq/dL 80/3133 (2.6) < 0.0001 34/1182 (2.9) < 0.0001
   Sodium > 145 mEq/dL 74/3600 (2.1) < 0.0001 34/1206 (2.8) < 0.0001
   Bands > 32% 50/5345 (0.9) 0.1239 26/1813 (1.4) 0.6021
   White blood cells > 27,000/mm3 54/5096 (1.1) 0.5840 35/1980 (1.8) 0.0557
Vital signs and mental status     
   Temperature ≤ 98°F 253/16,917 (1.5) < 0.0001 99/4780 (2.1) < 0.0001
   Severe altered mental statusa 135/6301 (2.1) < 0.0001 51/2255 (2.3) < 0.0001
   Temperature ≤ 98°F or severe altered mental statusa 336/21,140 (1.6) < 0.0001 129/6454 (2.0) < 0.0001
History and severe comorbidities     
   Metastatic cancer 62/3245 (1.9) 0.0001 25/1262 (2.0) 0.0285
   Tumor 41/2693 (1.5) 0.0786 19/1136 (1.7) 0.2570
   Cachexiab 123/4549 (2.7) < 0.0001 70/2392 (2.9) < 0.0001
Other variables     
   Pre-admission within 30 days 276/11,215 (2.5) < 0.0001 125/4603 (2.7) < 0.0001
   Admitted from other healthcare facility 281/12,813 (2.2) < 0.0001 133/5581 (2.4) < 0.0001
   Mechanical ventilation at admission 136/5864 (2.3) < 0.0001 84/2695 (3.1) < 0.0001
  1. aSevere altered mental status defined as Glasgow Coma Scale less than 5 or a designation of coma by a physician.
  2. bCachexia defined by ICD-9 secondary diagnosis code.