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Table 1 Effect of LPS, 1400 W and simvastatin on maximum response and potency of vasoconstrictor agent on the PCA

From: Pre-treatment with simvastatin prevents LPS-induced hyporesponsiveness of porcine isolated coronary artery

 

KCl

U46619

Incubation conditions

Maximum (g wt)

-log EC50

Maximum (g wt)

-log EC50

Control (n = 12)

10.23 ± 0.71

1.56 ± 0.04

10.39 ± 0.71

7.52 ± 0.08

LPS

6.83 ± 0.48*

1.60 ± 0.04

6.77 ± 0.80**

7.64 ± 0.06

LPS then 1400 W

9.35 ± 1.21

1.64 ± 0.06

9.41 ± 0.46

7.54 ± 0.04

Control (n = 18)

12.13 ± 0.58

1.55 ± 0.01

13.46 ± 0.51

7.83 ± 0.01

LPS

8.41 ± 0.58**

1.51 ± 0.02

9.90 ± 0.47**

7.75 ± 0.06

Simvastatin and LPS

11.82 ± 0.34

1.53 ± 0.03

13.92 ± 0.38

7.73 ± 0.04

  1. Data presented as mean ± SEM (n = 12 to 18). *P < 0.05, **P < 0.01, denotes a statistically significant difference from control.
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Critical Care

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