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Volume 13 Supplement 4

Sepsis 2009

Disseminated intravascular coagulation during human septic shock: relation with lactate levels

Introduction

The exact pathogenic role of disseminated intra-vascular coagulation (DIC) during septic shock is incompletely understood.

Objective

We studied the relation between sensitive and specific markers for DIC and lactate levels in the course of time, to evaluate whether DIC could contribute to microvascular obstruction and tissue hypoxygenation.

Methods

We prospectively studied 14 consecutive septic shock patients with a pulmonary artery catheter in place. For 3 days after admission, hemodynamic variables, and plasma levels of lactate, thrombin-antithrombin complexes (TAT), tissue plasminogen activator (tPA), plasminogen activator inhibitor (PAI) and plasmin-α2-antiplasmin complexes and TNFα, IL-6 and complement activation product C3a were measured 6-hourly.

Results

Of the 14 patients, eight died in the ICU. Patients had a hyperdynamic circulation with tachycardia, mild hypotension and increased cardiac index. The course of TAT, tPA and particularly of PAI predicted the course of lactate levels, independently of hemodynamic and inflammatory factors. Lactate and PAI elevations persisted in nonsurvivors versus survivors.

Conclusion

Our observations show that, in the course of human septic shock, activation of coagulation and, particularly, inhibition of activated fibrinolysis are independently associated with hyperlactatemia. This suggests a contribution of DIC resulting from a coagulation/fibrinolysis imbalance to microvascular obstruction, tissue hypoxygenation and thereby to ultimate demise.

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Correspondence to KJ Hartemink.

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Hartemink, K., Hack, C. & Groeneveld, A. Disseminated intravascular coagulation during human septic shock: relation with lactate levels. Crit Care 13, P35 (2009). https://doi.org/10.1186/cc8091

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Keywords

  • Septic Shock
  • Cardiac Index
  • Complement Activation
  • Lactate Level
  • Tissue Plasminogen Activator