Sesamol attenuates septic hypotension through peroxisome proliferator-activated receptor activation after the onset of systemic inflammatory response
© BioMed Central Ltd 2009
Published: 11 November 2009
Hypotension is well relative to the high mortality of sepsis. Sesamol increases the survival rate of septic mice. However, the effect of sesamol on septic hypotension after the onset of systemic inflammation has never been studied. The aim of the study is to investigate the effect of sesamol on septic hypotension.
Wistar rats, lipopolysaccharide (LPS) (derived from Escherichia coli, serotype O55:B5), and sesamol were used in this study.
Hypotension was induced by injecting LPS intravenously. Mean arterial pressure was measured using an invasive blood pressure system. Serum nitrite and cytokine levels were determined using the Griess reaction and ELISA, respectively. Peroxisome proliferator-activated receptor (PPAR) activation was measured using a PPAR assay kit.
LPS administration significantly increased the serum TNFα level at 1 hour. Sesamol treated 1 hour after LPS administration inhibited the LPS-associated blood pressure decrease. Sesamol failed to decrease the LPS-induced nitrite production, but decreased the LPS-induced TNFα and IL-1β production after the onset of systemic inflammation. Sesamol enhanced the IL-10 production in serum and the PPAR activation in white blood cells.
Sesamol may attenuate septic hypotension through alternating cytokine production by PPAR activation after the onset of systemic inflammatory response.