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Volume 13 Supplement 4

Sepsis 2009

  • Poster presentation
  • Open Access

Nandrolone abuse aggravates septic shock

  • 1,
  • 1, 2 and
  • 1, 2
Critical Care200913 (Suppl 4) :P4

https://doi.org/10.1186/cc8060

  • Published:

Keywords

  • Steroid
  • mRNA Expression
  • Serum Level
  • Septic Shock
  • Emergency Medicine

Introduction

One million individuals in the United States alone are estimated to be current or past users of anabolic-androgenic steroid.

Methods

To investigate the effects of nandrolone, an anabolic-androgenic steroid, 108 6-week-old male BALB/c inbred mice were used (minimal lethal dose n = 30, high-dose vs. low-dose n = 24, screening surrogates n = 6, and surrogates n = 48). Mice were sacrificed at 0, 3 or 6 hours after septic shock induction. The serum levels of malondialdehyde, liver TNFα and spleen IFNγ in mice with septic shock were analyzed. The gene expression of insulin-like growth factor 1, insulin-like growth factor type 1 receptor and insulin-like growth factor binding proteins were also studied.

Results

Nandrolone significantly increased serum malondialdehyde at 0, 3 and 6 hours (P = 0.004, 0.006 and 0.004), and liver TNFα at 0 and 6 hours (P = 0.04 and 0.016). It also increased the spleen IFNγ level at 0 and 6 hours (P = 0.031 and 0.01). Compared with 0 hours, the data indicated that nandrolone increases lung insulin-like growth factor type 1 receptor, insulin-like growth factor binding protein 1 and insulin-like growth factor binding protein 2 mRNA expression at 6 hours (P < 0.05). These indicated changes due to nandrolone.

Conclusion

Nandrolone abuse hastens mortality due to septic shock and increases serum malondialdehyde, liver TNFα, spleen IFNγ level and lung insulin-like growth factor type 1 receptor mRNA, as well as lung insulin-like growth factor binding proteins. Nandrolone abuse may aggravate septic shock.

Authors’ Affiliations

(1)
Department of Research, Changhua Christian Hospital, Changhua, Taiwan
(2)
Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan

Copyright

© BioMed Central Ltd 2009

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