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Table 1 Second order inactivation rate constants (k) for VX-166 against a panel of nine caspases (n = 4 per assay).

From: VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

Recombinant caspase K (M/s) × 103
Caspase-1 >1000 a
Caspase-2 6.19 ± 0.51
Caspase-3 1171 ± 183
Caspase-4 480 ± 32
Caspase-6 77 ± 3.0
Caspase-7 526 ± 1.5
Caspase-8 194 ± 52
Caspase-9 131 ± 21
Caspase-10 49 ± 3.8
  1. A larger number for an inactivation rate constant k indicates a greater degree of inactivation.
  2. a inactivation rate was above the upper limit of the assay.