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Table 1 Second order inactivation rate constants (k) for VX-166 against a panel of nine caspases (n = 4 per assay).

From: VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

Recombinant caspase

K (M/s) × 103

Caspase-1

>1000 a

Caspase-2

6.19 ± 0.51

Caspase-3

1171 ± 183

Caspase-4

480 ± 32

Caspase-6

77 ± 3.0

Caspase-7

526 ± 1.5

Caspase-8

194 ± 52

Caspase-9

131 ± 21

Caspase-10

49 ± 3.8

  1. A larger number for an inactivation rate constant k indicates a greater degree of inactivation.
  2. a inactivation rate was above the upper limit of the assay.
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Critical Care

ISSN: 1364-8535