Low tissue oxygen saturation at the end of early goal-directed therapy is associated with worse outcome in critically ill patients

Table 2 Contribution from systemic and peripheral physiological variables on repeated tissue oxygen saturation measurements during resuscitation

Variable	StO₂ estimation coefficient (95% confidence interval)	P-value	Number of observations
Systemic hemodynamic
Heart rate	-0.08 (-0.23 to 0.63)	0.26	88
Mean arterial pressure	-0.05 (-0.22 to 0.11)	0.51	88
Central venous oxygen saturation	0.11 (-0.13 to 0.36)	0.36	88
Peripheral circulation
Clinical abnormalities	5.7 (2.0 to 9.6)	0.004	88
Peripheral flow index	8.1 (2.3 to 13.1)	0.005	88
R_incStO₂	3.9 (2.1 to 6.0)	0.002	44

Using the linear mixed-models analysis, we assessed the magnitude of contribution from each systemic and peripheral physiological variable on all repeated tissue oxygen saturation (StO₂) measurements during the 8-hour period of resuscitation. R_incStO₂, rate of StO₂ increase after the vascular occlusion test.

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