Microcirculatory changes and skeletal muscle oxygenation measured at rest by non-infrared spectroscopy in patients with and without diabetes undergoing haemodialysis

De Blasi, Roberto Alberto; Luciani, Remo; Punzo, Giorgio; Arcioni, Roberto; Romano, Rocco; Boezi, Marta; Menè, Paolo

doi:10.1186/cc8007

Critical Care

Table 4 Variables measured during hemodialysis in healthy subjects and in patients with and without diabetes

From: Microcirculatory changes and skeletal muscle oxygenation measured at rest by non-infrared spectroscopy in patients with and without diabetes undergoing haemodialysis

		Patients without diabetes (n = 10)				Patients with diabetes (n = 10)
Variable	Healthy subjects (n = 22)	T0	T1	T2	T3	T0	T1	T2	T3
Body weight (kg)	76.35 ± 18.34	73.57^a ± 18.96	71.82^c ± 17.80	69.62 ± 18.76	68.21 ± 19.51	92.21^a ± 21.05	90.82^c ± 25.13	89.87 ± 21.01	88.34 ± 22.98
Mean arterial pressure (mmHg)	-	93.5 ± 11.1	95.2 ± 9.2	96.2 ± 7.2	97.2 ± 10.9	98.6 ± 18.5	99.1 ± 11.0	98.4 ± 13.4	101.3 ± 11.6
[HbT] (μmol/l)	54.18 ± 19.59	44.31^a ± 19.71	58.24 ± 18.67	60.43 ± 17.52	62.71 ± 18.32	44.17^a ± 18.61	60.32 ± 21.10	63.82^b ± 24.32	73.83 ± 35.40
[HHb] (μmol/l)	20.44 ± 9.85	22.69^a ± 16.10	31.37 ± 17.82	32.83 ± 18.43	35.92 ± 19.23	21.86^a ± 10.34	30.34 ± 11.32	32.75 ± 11.23	35.84 ± 14.07
[HbO₂] (μmol/l)	33.74^e ± 14.17	21.62 ± 11.67	26.87 ± 11.34	27.60 ± 10.43	26.79 ± 12.32	22.31^a ± 11.86	29.98 ± 13.45	31.07 ± 14.54	37.99 ± 18.54
CtO₂ (ml O₂/100 ml)	0.29^e ± 0.12	0.18 ± 0.13	0.23 ± 0.08	0.20 ± 0.14	0.21 ± 0.11	0.19^a ± 0.09	0.24 ± 0.10	0.26^b ± 0.09	0.32 ± 0.11
Microvascular compliance (ml/mmHg/100 ml)	0.11^e ± 0.12	0.161^a ± 0.110	0.061^c ± 0.041	0.010 ± 0.010	0.006 ± 0.001	0.221^a ± 0.140	0.045 ± 0.051	0.019 ± 0.015	0.013 ± 0.010
StO₂ (%)	62.3 ± 7.3	51.5 ± 21.4	50.3 ± 19.9	49.1 ± 22.9	46.1 ± 21.3	49.1 ± 16.6	47.9 ± 13.4	48.7 ± 12.8	50.3 ± 12.3
mHF (μmol/min/100 ml)	-	1.81 ± 1.21	1.74 ± 0.98	2.52 ± 1.61	1.64 ± 0.89	1.76^c ± 0.82	2.10 ± 0.74	3.15 ± 1.01	3.11 ± 1.52
mBF (ml/min/100 ml)	4.01 ± 1.98	3.12 ± 2.12	3.121 ± 1.55	4.33 ± 2.75	2.83 ± 1.54	3.02^d ± 1.78	3.76 ± 1.32	5.42 ± 1.73	5.03 ± 2.41
mVO₂ (ml/min/100 ml)	0.23 ± 0.13	0.34 ± 0.27	0.35 ± 0.15	0.42 ± 0.22	0.36 ± 0.12	0.29^c ± 0.15	0.41^d ± 0.13	0.72 ± 0.21	0.58 ± 0.20

[HbT], total haemoglobin concentration; [HHb], deoxygenated haemoglobin concentration; [HbO₂], oxygenated haemoglobin concentration; CtO₂, tissue oxygen content; StO₂, tissue oxygen saturation; mHF, muscular haemoglobin flow; mBF, muscular blood flow; mVO₂, muscle oxygen consumption. Wilcoxon test: ^aP < 0.05 vs. beginning of the second hour (T1), beginning of the third hour (T2), beginning of the fourth hour (T3); ^bP < 0.05 vs. T3; ^cP < 0.05 vs. T2, T3; ^dP < 0.05 vs. T2. Mann-Whitney U test: ^eP < 0.05 vs. predialysis (T0) of patients with diabetes.

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