| Baseline | 12 hours | 24 hours | 36 hours | 48 hours |
---|---|---|---|---|---|
HR (bpm) | Â | Â | Â | Â | Â |
TP | 95 ± 16 | 85 ± 19* | 83 ± 21* | 71 ± 14*‡§ | 71 ± 16*‡§ |
AVP | 100 ± 22 | 98 ± 24 | 97 ± 27 | 92 ± 24†| 93 ± 25†|
NE | 97 ± 21 | 92 ± 26 | 99 ± 29 | 95 ± 24†| 96 ± 21†|
CI (L/min/m) | Â | Â | Â | Â | Â |
TP | 4.0 ± 1.0 | 3.9 ± 1.0 | 3.7 ± 0.8 | 3.4 ± 0.6 | 3.5 ± 0.6 |
AVP | 4.0 ± 1.1 | 4.2 ± 1.4 | 4.3 ± 1.1 | 3.9 ± 1.1 | 4.2 ± 1.9 |
NE | 4.0 ± 1.0 | 3.9 ± 1.0 | 4.1 ± 1.1 | 3.9 ± 1.2 | 3.9 ± 1.5 |
SVI (mL/beats/m) | Â | Â | Â | Â | Â |
TP | 46 ± 13 | 46 ± 13 | 47 ± 12 | 48 ± 10 | 50 ± 10 |
AVP | 41 ± 12 | 43 ± 12 | 46 ± 10 | 44 ± 12 | 47 ± 18 |
NE | 43 ± 13 | 44 ± 14 | 44 ± 15 | 43 ± 16 | 42 ± 15 |
MAP (mmHg) | Â | Â | Â | Â | Â |
TP | 53 ± 6 | 70 ± 3* | 71 ± 3* | 72 ± 3* | 71 ± 4* |
AVP | 53 ± 4 | 70 ± 3* | 70 ± 3* | 71 ± 3* | 71 ± 3* |
NE | 54 ± 3 | 70 ± 4* | 71 ± 2* | 7 0 ± 3* | 71 ± 3* |
MPAP (mmHg) | Â | Â | Â | Â | Â |
TP | 25 ± 4 | 27 ± 4* | 27 ± 4* | 27 ± 5* | 28 ± 5* |
AVP | 24 ± 4 | 28 ± 5* | 28 ± 5* | 28 ± 5* | 29 ± 4* |
NE | 24 ± 7 | 28 ± 7* | 29 ± 7* | 29 ± 5* | 30 ± 7* |
PAOP (mmHg) | Â | Â | Â | Â | Â |
TP | 15 ± 2 | 17 ± 2 | 17 ± 2 | 17 ± 2 | 17 ± 2 |
AVP | 15 ± 2 | 17 ± 2* | 17 ± 4* | 17 ± 3* | 17 ± 2* |
NE | 15 ± 2 | 15 ± 2 | 16 ± 2 | 16 ± 2 | 16 ± 3 |
RAP (mmHg) | Â | Â | Â | Â | Â |
TP | 11 ± 3 | 12 ± 3 | 14 ± 3* | 13 ± 3 | 13 ± 3 |
AVP | 12 ± 3 | 15 ± 3* | 14 ± 3* | 15 ± 3* | 15 ± 4* |
NE | 12 ± 3 | 13 ± 3 | 14 ± 3 | 14 ± 4 | 14 ± 4 |
SVRI (dyne·s/cm/m) |  |  |  |  |  |
TP | 886 ± 291 | 1271 ± 334* | 1287 ± 304* | 1376 ± 241* | 1348 ± 275* |
AVP | 861 ± 246 | 1157 ± 407* | 1091 ± 325* | 1235 ± 334* | 1254 ± 531* |
NE | 874 ± 220 | 1237 ± 320* | 1208 ± 348* | 1266 ± 386* | 1319 ± 471* |
PVRI (dyne·s/cm/m) |  |  |  |  |  |
TP | 196 ± 61 | 227 ± 99 | 219 ± 89 | 256 ± 108 | 260 ± 117 |
AVP | 200 ± 83 | 243 ± 108 | 230 ± 128 | 254 ± 148 | 264 ± 134 |
NE | 192 ± 115 | 266 ± 106* | 275 ± 122* | 298 ± 133* | 313 ± 202* |
RVSWI (g/m/beat) | Â | Â | Â | Â | Â |
TP | 8 ± 4 | 9 ± 4 | 8 ± 5 | 9 ± 4 | 10 ± 4 |
AVP | 7 ± 3 | 8 ± 3 | 9 ± 3* | 8 ± 3 | 9 ± 4* |
NE | 7 ± 3 | 9 ± 4* | 9 ± 3* | 8 ± 3* | 9 ± 4* |
LVSWI (g/m/beat) | Â | Â | Â | Â | Â |
TP | 22 ± 7 | 33 ± 9* | 35 ± 10* | 37 ± 8* | 37 ± 9* |
AVP | 21 ± 7 | 31 ± 8* | 32 ± 6* | 33 ± 9* | 34 ± 14* |
NE | 22 ± 7 | 33 ± 11* | 33 ± 12* | 32 ± 13* | 31 ± 11* |
Fluids (mL/24 h) | Â | Â | Â | Â | Â |
TP |  |  | 4833 ± 783 |  | 4353 ± 853 |
AVP |  |  | 4860 ± 686 |  | 4513 ± 781 |
NE |  |  | 4707 ± 860 |  | 4807 ± 853 |