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Table 2 Hemodynamic variables

From: Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study

  Baseline 12 hours 24 hours 36 hours 48 hours
HR
(bpm)
     
TP 95 ± 16 85 ± 19* 83 ± 21* 71 ± 14*‡§ 71 ± 16*‡§
AVP 100 ± 22 98 ± 24 97 ± 27 92 ± 24 93 ± 25
NE 97 ± 21 92 ± 26 99 ± 29 95 ± 24 96 ± 21
CI
(L/min/m)
     
TP 4.0 ± 1.0 3.9 ± 1.0 3.7 ± 0.8 3.4 ± 0.6 3.5 ± 0.6
AVP 4.0 ± 1.1 4.2 ± 1.4 4.3 ± 1.1 3.9 ± 1.1 4.2 ± 1.9
NE 4.0 ± 1.0 3.9 ± 1.0 4.1 ± 1.1 3.9 ± 1.2 3.9 ± 1.5
SVI
(mL/beats/m)
     
TP 46 ± 13 46 ± 13 47 ± 12 48 ± 10 50 ± 10
AVP 41 ± 12 43 ± 12 46 ± 10 44 ± 12 47 ± 18
NE 43 ± 13 44 ± 14 44 ± 15 43 ± 16 42 ± 15
MAP
(mmHg)
     
TP 53 ± 6 70 ± 3* 71 ± 3* 72 ± 3* 71 ± 4*
AVP 53 ± 4 70 ± 3* 70 ± 3* 71 ± 3* 71 ± 3*
NE 54 ± 3 70 ± 4* 71 ± 2* 7 0 ± 3* 71 ± 3*
MPAP
(mmHg)
     
TP 25 ± 4 27 ± 4* 27 ± 4* 27 ± 5* 28 ± 5*
AVP 24 ± 4 28 ± 5* 28 ± 5* 28 ± 5* 29 ± 4*
NE 24 ± 7 28 ± 7* 29 ± 7* 29 ± 5* 30 ± 7*
PAOP
(mmHg)
     
TP 15 ± 2 17 ± 2 17 ± 2 17 ± 2 17 ± 2
AVP 15 ± 2 17 ± 2* 17 ± 4* 17 ± 3* 17 ± 2*
NE 15 ± 2 15 ± 2 16 ± 2 16 ± 2 16 ± 3
RAP
(mmHg)
     
TP 11 ± 3 12 ± 3 14 ± 3* 13 ± 3 13 ± 3
AVP 12 ± 3 15 ± 3* 14 ± 3* 15 ± 3* 15 ± 4*
NE 12 ± 3 13 ± 3 14 ± 3 14 ± 4 14 ± 4
SVRI
(dyne·s/cm/m)
     
TP 886 ± 291 1271 ± 334* 1287 ± 304* 1376 ± 241* 1348 ± 275*
AVP 861 ± 246 1157 ± 407* 1091 ± 325* 1235 ± 334* 1254 ± 531*
NE 874 ± 220 1237 ± 320* 1208 ± 348* 1266 ± 386* 1319 ± 471*
PVRI
(dyne·s/cm/m)
     
TP 196 ± 61 227 ± 99 219 ± 89 256 ± 108 260 ± 117
AVP 200 ± 83 243 ± 108 230 ± 128 254 ± 148 264 ± 134
NE 192 ± 115 266 ± 106* 275 ± 122* 298 ± 133* 313 ± 202*
RVSWI
(g/m/beat)
     
TP 8 ± 4 9 ± 4 8 ± 5 9 ± 4 10 ± 4
AVP 7 ± 3 8 ± 3 9 ± 3* 8 ± 3 9 ± 4*
NE 7 ± 3 9 ± 4* 9 ± 3* 8 ± 3* 9 ± 4*
LVSWI
(g/m/beat)
     
TP 22 ± 7 33 ± 9* 35 ± 10* 37 ± 8* 37 ± 9*
AVP 21 ± 7 31 ± 8* 32 ± 6* 33 ± 9* 34 ± 14*
NE 22 ± 7 33 ± 11* 33 ± 12* 32 ± 13* 31 ± 11*
Fluids
(mL/24 h)
     
TP    4833 ± 783   4353 ± 853
AVP    4860 ± 686   4513 ± 781
NE    4707 ± 860   4807 ± 853
  1. AVP = arginine vasopressin; CI = cardiac index; HR = heart rate; LVSWI = left ventricular stroke work index; MAP = mean arterial pressure; MPAP = mean pulmonary arterial pressure; NE = norepinephrine; PAOP = pulmonary artery occlusion pressure; PVRI = pulmonary vascular resistance index; RAP = right atrial pressure; RVSWI = right ventricular stroke work index; SVI = stroke volume index; SVRI = systemic vascular resistance index; TP = terlipressin.
  2. *P < 0.05 vs. baseline (significant time effect); P < 0.05 vs. TP (significant group effect); P < 0.05 vs. AVP (significant group effect); §P < 0.05 vs. NE (significant group effect).