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Table 1 Demographic data and clinical characteristics

From: Critical illness-related corticosteroid insufficiency in patients with severe acute biliary pancreatitis: a prospective cohort study

  All Patients
(n = 32)
Hospital Survivors
(n = 25)
Hospital Non-survivors
(n = 7)
P value
Age (years) 68 (55 to 79) 68 (55 to 81) 75 (55 to 80) NS (0.293)
Gender (M/F) 12/20 9/16 3/4 NS (1.000)
BUN 15.5 (10.5 to 36.5) 14 (8.5 to 20.5) 40 (17 to 80) < 0.001
Serum creatinine (mg/dl) 1.1 (0.6 to 1.9) 0.9 (0.6 to 1.4) 3.7 (2 to 4.2) < 0.001
Bilirubin (mg/dl) 1.6 (0.8 to 3.2) 1.5 (0.7 to 2.6) 5.1 (1.2 to 11.5) 0.006
Albumin (g/l) 2.8 (2.4 to 3) 2.8 (2.4 to 3.1) 2.6 (2.3 to 2.8) NS (0.090)
INR 1.2 (1.2 to 1.4) 1.2 (1.2 to 1.4) 1.3 (1.2 to 1.5) NS (0.399)
MAP (mmHg) 79 (60 to 90) 81 (68 to 92) 60 (57 to 75) 0.041
SOFA score on the day of SST 5 (3 to 9) 4 (2.3 to 6.8) 12 (10 to 16) 0.001
APACHE II score on the day of SST 15 (10 to 20) 14 (9.5 to 18) 20 (15 to 36) 0.006
Ranson score 5 (3 to 6) 4 (3 to 5.5) 8 (5 to 9) 0.005
CIRCI (%) 11 (34.4) 6 (24) 5 (71.4) 0.032
Baseline cortisol (μg/dL) 21.6 (17.1 to 36) 20.7 (16.4 to 31.6) 28 (19.1 to 39.1) NS (0.368)
Peak cortisol (μg/dL) 39.2 (32.1 to 46.8) 39.2 (32.5 to 47.1) 39.1 (29.7 to 46) NS (0.316)
Cortisol increment (μg/dL) 14.5 (3.3 to 25.3) 17.4 (8.3 to 27.1) 7.2 (1.7 to 12) 0.019
Bacteremia (%) 14 (43.8) 10 (40) 4 (57.1) NS (0.669)
Number of organ dysfunction on the day of SST 2 (1 to 3) 1 (1 to 2) 4 (3 to 5) < 0.001
   Respiratory dysfunction (%) 23 (71.9) 16 (69.6) 7 (100) NS (0.149)
   Coagulation dysfunction (%) 7 (21.9) 3 (12) 4 (57.1) 0.026
   Cardiovascular dysfunction (%) 10 (31.3) 5 (20) 5 (71.4) 0.019
   CNS dysfunction (%) 14 (43.8) 8 (32) 6 (85.7) 0.0287
   Renal dysfunction (%) 12 (37.5) 5 (20) 7 (100) < 0.001
  1. APACHE = Acute Physiology and Chronic Health Evaluation; BUN = blood urea nitrogen; CIRCI = critical illness related corticosteroid insufficiency; CNS = central nervous system; F = female; INR = international normalized ratio; M = male; MAP = mean arterial pressure; NS = not significant; SOFA = sequential organ failure assessment; SST = short corticotropin stimulation test.