S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

Table 5 Comparison of values for biomarkers between no-return and return to independent daily life

Authors	Year	Ref	n	on admission	Day 1	24 hours	Day 2	48 hours	Day 3
NSE
Tiainen and colleagues (hypothermia)	2003	[26]	36	-	-	NM	NM	NM	-
Tiainen and colleagues (normothermia)	2003	[26]	34	-	-	NM	NM	NM	-
Rosen and colleagues	2001	[29]	66	-	P < 0.05	-	P < 0.01	-	P < 0.01
Bottiger and colleagues	2001	[18]	66	NS	-	P < 0.05	-	P < 0.05	-
Schoerkhuber and colleagues	1999	[30]	56	NS	P < 0.01	P < 0.05	-	P < 0.01	-
S-100B
Tiainen and colleagues (hypothermia)	2003	[26]	36	-	-	NM	NM	NM	-
Tiainen and colleagues (normothermia)	2003	[26]	34	-	-	NM	NM	NM	-
Mussack and colleagues	2002	[17]	20	NM	NM	-	-	-	-
Rosen and colleagues	2001	[29]	66	-	P < 0.01	-	P < 0.01	-	P < 0.01
Bottiger and colleagues	2001	[18]	66	P < 0.05	-	P < 0.05	-	P < 0.05	-

NM = not mentioned for statistical comparison; NS = not significance; NSE = neuron specific enolase, Ref = references.

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