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Archived Comments for: Macrophage migration inhibitory factor, infection, the brain, and corticosteroids

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  1. Many facets of bacterial meningitis

    Heikki Savolainen, Dept. of Occup. Safety & Hlth., Tampere, Finland

    28 July 2009

    Dear Editor,

    The authors rightly point out the central role of macrophages in the severe meningitis. They are also the important source of NO associated classically with the dilatation of blood vessels at 4-20 nM concentrations. Larger, 100-340 nM nitrogen oxide concentrations compete with oxygen at the cytochrome oxidase thereby adding a histotoxic component to the inflammation (Antunes et al, 2004).

    Thus, one wonders what all modalities of a treatment aimed at the macrophage functions might be.

    Antunes A, Boveris A, Cadenas E. Proc Ntnl Acad Sci USA. 2004; 101: 16774.

    Competing interests

    None

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