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Figure 5 | Critical Care

Figure 5

From: Unfractionated heparin and enoxaparin reduce high-stretch ventilation augmented lung injury: a prospective, controlled animal experiment

Figure 5

Plasminogen-activator inhibitor-1 (PAI-1)-deficient mice reduced lung stretch–induced neutrophil sequestration. Wild-type or PAI-1-/- mice were ventilated at VT 30 ml for 5 hours with room air. (a) Neutrophils in bronchoalveolar lavage fluid of lung tissue (n = 6 per group). (b) MPO assay of lung tissue (n = 6 per group). *P < 0.05 versus control, nonventilated mice; † P < 0.05 versus PAI-1-/- mice.

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Critical Care

ISSN: 1364-8535