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Table 3 Performance of serum IL-6 and IL-8 for the diagnosis of acute kidney injury at various times after cardiopulmonary bypass

From: Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study

  Sensitivity (%) Specificity (%) Positive predictive value (%)* Negative predictive value (%)* Area under the ROC curve
IL-6 at 2 hours      0.76
≥175 pg/ml 44 85 63 73  
≥125 pg/ml 78 80 69 87  
≥75 pg/ml 83 25 39 73  
IL-6 at 12 hours      0.71
≥175 pg/ml 17 100 100 68  
≥125 pg/ml 22 100 100 70  
≥75 pg/ml 50 89 72 76  
IL-8 at 2 hours      0.74
≥100 pg/ml 44 80 56 72  
≥70 pg/ml 67 65 52 78  
≥40 pg/ml 83 45 46 83  
IL-8 at 12 hours      0.82
≥100 pg/ml 18 100 100 68  
≥70 pg/ml 35 100 100 73  
≥40 pg/ml 71 74 60 82  
  1. *Because positive and negative predictive values will vary based on AKI prevalence, we assumed a prevalence of 36%, as in [17].