Serum Interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study

Table 3 Performance of serum IL-6 and IL-8 for the diagnosis of acute kidney injury at various times after cardiopulmonary bypass

	Sensitivity (%)	Specificity (%)	Positive predictive value (%)*	Negative predictive value (%)*	Area under the ROC curve
IL-6 at 2 hours					0.76
≥175 pg/ml	44	85	63	73
≥125 pg/ml	78	80	69	87
≥75 pg/ml	83	25	39	73
IL-6 at 12 hours					0.71
≥175 pg/ml	17	100	100	68
≥125 pg/ml	22	100	100	70
≥75 pg/ml	50	89	72	76
IL-8 at 2 hours					0.74
≥100 pg/ml	44	80	56	72
≥70 pg/ml	67	65	52	78
≥40 pg/ml	83	45	46	83
IL-8 at 12 hours					0.82
≥100 pg/ml	18	100	100	68
≥70 pg/ml	35	100	100	73
≥40 pg/ml	71	74	60	82

*Because positive and negative predictive values will vary based on AKI prevalence, we assumed a prevalence of 36%, as in [17].

ISSN: 1364-8535