Severe multiple injury results in a rapid decline of intracellular cytokine synthesis by monocytes within the first 24 hours after trauma. Cytokine de novo synthesis capacity was determined using an ex vivo whole blood approach in response to lipopolysaccharide (LPS). Results are calculated as percentage of cytokine positive CD14+ monocytes. Blood samples were drawn on admission, 6, 12, 24, 48, and 72 hours post trauma. Data are given as boxplots (median, 5th, 95th percentile). n = 13 patients (grey), n = 8 controls (white). # P < 0.05 vs. control group; * P < 0.05 vs. admission values.