Table 5 Odds ratio estimates of 28-day mortality for patients receiving DrotAA

Age, years

≤49 vs 50 to 64

0.524 (0.2203 to 1.2461)

0.144

≤49 vs 65 to 74

0.251 (0.102 to 0.617)

0.003*

≤49 vs ≥75

0.269 (0.106 to 0.678)

0.005*

50 to 64 vs 65 to 74

0.479 (0.2146 to 1.0676)

0.072

50 to 64 vs ≥75

0.513 (0.2226 to 1.1802)

0.116

65 to 74 vs ≥75

1.071(0.4524 to 2.5346)

0.876

Time to treatment

Delay in time from first sepsis-induced organ dysfunction to start of study drug (six-hour intervals)

1.231 (1.053 to 1.439)

0.009*

Laboratory values

Increase in creatinine from baseline to day 1 (50 μmol/L intervals)

1.317 (1.033 to 1.679)

0.026*

Increase in platelets from baseline to day 1 (50 × 10⁹/L unit intervals)

0.658 (0.442 to 0.978)

0.039*