Brain natriuretic peptide levels have diagnostic and prognostic capability for cardio-renal syndrome type 4 in intensive care unit patients

Table 2 Associations of BNP levels at admission with clinical and laboratory parameters.

Variables	Correlation coefficients	P value
Age	-0.146	0.090
BUN	-0.063	0.464
Serum Cr	0.013	0.884
Blood pressure
Systolic blood pressure	0.297	0.001
Diastolic blood pressure	0.238	0.005
Heart rate	0.019	0.827
C-reactive protein	-0.074	0.407
WBC	-0.056	0.529
Haemoglobin	-0.015	0.859
Protein	0.104	0.230
Albumin	0.023	0.793
SAPS II	0.025	0.777
SOFA	0.099	0.257
Cardiac markers
CK	0.067	0.454
CK-MB	0.056	0.529
Troponin I	0.066	0.460
Echocardiographic data
LAD	0.277	0.076*
LV diameter at end systole	0.347	0.033*
LV diameter at end diastole	0.283	0.066*
LV mass index	0.526	0.000*
E/A ratio	-0.125	0.495*
Deceleration time	0.198	0.303*
LVEF	-0.391	0.008*
Systolic dysfunction (EF <50% vs. ≥ 50%)	-	0.032^†
Diastolic dysfunction (grade ≥ II vs. <I)	-	0.117^†
Mechanical ventilation (yes vs. no)	-	0.041^#

*Spearman correlation, ^†Mann-Whitney U test, ^#student's t test.
BNP = brain natriuretic peptide; BUN = blood urea nitrogen; CK = creatine kinase; CK-MB = creatinine kinase-MB; Cr = creatinine; E/A = ratio of E (peak mitral flow velocity of the early rapid filling) to A (peak velocity of the late filling due to atrial contration); EF = ejection fraction; LAD = left atrial dimension; LV = left ventricle; LVEF = left ventricular ejection fraction; SAPS II = simplified acute physiology score II; SOFA = sequential organ failure assessment; WBC = white blood cell.

ISSN: 1364-8535