Volume 13 Supplement 3

Fifth International Symposium on Intensive Care and Emergency Medicine for Latin America

Open Access

Factors related to the mortality of patients with severe sepsis and septic shock

  • RL Machado1,
  • R Bak1,
  • A Bicudo1,
  • CMN David1,
  • RR Luiz1,
  • GMM Oliveira1 and
  • C Salomão1
Critical Care200913(Suppl 3):P18


Published: 23 June 2009


It is important to know the factors related to the mortality of the increasing number of older people admitted to the ICU.


To evaluate variables related to intrahospital mortality within 28 days of older people diagnosed with severe sepsis and septic shock admitted to a clinical ICU.


Clinical and laboratory variables of 152 patients ≥ 65 years old admitted with severe sepsis and septic shock were assembled during 28 days. The variables were obtained on days 1, 3, 5, 7, 14 and 28. The chi-square and Mann–Whitney tests were used for statistical analysis. Results were considered relevant when P < 0.05.


The average age was 82 ± 9 years, with 64.5% women, and the mortality rate was 47.4%. Mortality was related to lower ICU length of stay (P < 0.001), shock (OR = 10.42, 95% CI = 3.79 to 28.62), high levels of lactate on the third day (P = 0.05), and positive troponin I on days 1 and 3 (P < 0.001).


Persistence of high levels of lactate, total amount of organic failures, shock, mechanical ventilation needs and previous renal disease were related to mortality in older people diagnosed with severe sepsis and septic shock.

Authors’ Affiliations

Prontocor Universidade Federal do Rio de Janeiro


© BioMed Central Ltd 2009