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Factors related to the mortality of patients with severe sepsis and septic shock

Introduction

It is important to know the factors related to the mortality of the increasing number of older people admitted to the ICU.

Objective

To evaluate variables related to intrahospital mortality within 28 days of older people diagnosed with severe sepsis and septic shock admitted to a clinical ICU.

Methods

Clinical and laboratory variables of 152 patients ≥ 65 years old admitted with severe sepsis and septic shock were assembled during 28 days. The variables were obtained on days 1, 3, 5, 7, 14 and 28. The chi-square and Mann–Whitney tests were used for statistical analysis. Results were considered relevant when P < 0.05.

Results

The average age was 82 ± 9 years, with 64.5% women, and the mortality rate was 47.4%. Mortality was related to lower ICU length of stay (P < 0.001), shock (OR = 10.42, 95% CI = 3.79 to 28.62), high levels of lactate on the third day (P = 0.05), and positive troponin I on days 1 and 3 (P < 0.001).

Conclusion

Persistence of high levels of lactate, total amount of organic failures, shock, mechanical ventilation needs and previous renal disease were related to mortality in older people diagnosed with severe sepsis and septic shock.

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Machado, R., Bak, R., Bicudo, A. et al. Factors related to the mortality of patients with severe sepsis and septic shock. Crit Care 13, P18 (2009). https://doi.org/10.1186/cc7820

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Keywords

  • Public Health
  • Mortality Rate
  • Lactate
  • Mechanical Ventilation
  • Renal Disease