Simulation of different administration schedules of 2 g daily vancomycin. Shown are simulated profiles of vancomycin daily plasma exposure achievable in a young male with normal renal function when administering the fixed 30 mg/kg per day dose separated into two or four intermittent infusions, or by continuous infusion (CI) after loading (loading dose [LD]). Simulation was performed using a two-compartment linear model by means of the Abbottbase Pharmacokinetic Systems program (PKS; v 1.10) from Abbott Laboratories Diagnostics Division. The dotted/dashed line refers to 10 mg/l. Reproduced with permission from Pea and coworkers . CLCr, creatinine clearance; SCr, serum creatinine.