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Table 2 Comparison of NSAID and aspirin use by cases versus controls

From: A multicentre case-control study of nonsteroidal anti-inflammatory drugs as a risk factor for severe sepsis and septic shock

Analysis

NSAID users (%)

OR (95% CI)

P value

  

Cases

Controls

  

Global (n = 152)a

NSAIDs and aspirin

27

28

0.93 (0.52 to 1.64)

0.79

 

NSAIDs

24

21

1.18 (0.64 to 2.19)

0.56

 

   Chronic treatment

4

5

0.86 (0.24 to 2.98)

0.78

 

   Acute treatment

20

16

1.40 (0.69 to 2.92)

0.32

 

Aspirin

5

10

0.47 (0.16 to 1.22)

0.09

Subgroup analysis

Diabetes (n = 20)a

    
 

   NSAIDs

20

5

4.00 (0.40 to 196.99)

0.18

 

   Aspirin

10

5

2.00 (0.40 to 196.99)

0.56

 

No diabetes (n = 132)a

    
 

   NSAIDs

24

23

1.05 (0.55 to 2.00)

0.88

 

   Aspirin

4

11

0.36 (0.10 to 1.05)

0.04b

 

Site of infection: lung (n = 71)a

    
 

   NSAIDs

14

15

0.90 (0.32 to 2.46)

0.82

 

   Aspirin

7

11

0.63 (0.16 to 2.17)

0.40

 

Site of infection: urinary tract (n = 30)a

    
 

   NSAIDs

27

30

0.83 (0.02 to 3.28)

0.76

 

   Aspirin

3

7

0.50 (0.01 to 9.60)

0.56

 

Site of infection: skin and soft tissue (n = 16)a

    
 

   NSAIDs

31

31

1.00 (0.07 to 13.80)

1.00

 

   Aspirin

0

6

- -

-

 

Site of infection: other (n = 35)a

    
 

   NSAIDs

37

20

2.50 (0.72 to 10.92)

0.11

 

   Aspirin

3

11

0.25 (0.01 to 2.53)

0.18

  1. aThe n values indicate the number of pairs. bThe apparent discordance between the confidence interval (CI) and statistical test results is due to the use of different but asymptotically equivalent statistical methods. NSAID, nonsteroidal anti-inflammatory drug; OR, odds ratio.