Thromboelastometry for the assessment of coagulation abnormalities in early and established adult sepsis: a prospective cohort study

Table 3 Results of thromboelastometry

Parameter	Normal ranges	0 hours	12 hours	24 hours	36 hours	48 hours	Discharge	Spearman
								r	P
CT-EXTEM	42 to 74	64.9 ± 7.6	66.0 ± 10.6	61.7 ± 9.6	63.7 ± 7.2	61.9 ± 7.3	57.4 ± 4.6*	0.09	0.36
CT-INTEM	137 to 246	195.9 ± 25.8	201.0 ± 31.4	199.8 ± 36.7	213.2 ± 41.1	216.3 ± 43.8	206.7 ± 40.6
CT-HEPTEM	137 to 246	197.1 ± 39.3	217.2 ± 58.1	212.2 ± 47.7	212.4 ± 40.0	205.8 ± 29.6	192.8 ± 34.2
CFT-EXTEM	46 to 148	97.0 ± 62.6	103.6 ± 79.2	99.3 ± 61.0	100.4 ± 64.8	94.5 ± 54.9	62.6 ± 30.7*	0.64	0.001
Alpha-EXTEM	63 to 81	73.9 ± 7.8	74.3 ± 7.1	74.0 ± 6.9	73.7 ± 6.8	74.5 ± 5.9	78.3 ± 4.1	-0.58	0.001
MCF-EXTEM	49 to 71	62.1 ± 11.2	62.1 ± 12.6	62.1 ± 12.1	62.1 ± 12.4	62.7 ± 11.6	67.4 ± 9.0*	-0.63	0.001
MCF-INTEM	52 to 72	63.7 ± 8.0	63.2 ± 7.6	61.9 ± 8.3	64.1 ± 7.7	64.6 ± 8.1	66.9 ± 8.4
MCF-HEPTEM	52 to 72	61.0 ± 8.9	59.6 ± 8.0	59.1 ± 9.4	60.6 ± 9.2	61.5 ± 8.4	64.1 ± 7.8*

Spearman rank correlation (r) is between the continuous values of Sequential Organ Failure Assessment (SOFA) score with thromboelastometric variables. *P < 0.05, versus baseline. alpha angle (°); CFT, clot formation time (seconds); CT, clotting time (seconds); EXTEM, activation of coagulation with tissue factor; HEPTEM, inhibition of heparin with heparinase; INTEM, activation of coagulation with thromboplastin; MCF, maximal clot firmness (mm).

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