Crystalloids versus colloids for goal-directed fluid therapy in major surgery

Table 2 Oxygen delivery, extraction, and other variables

	sDO₂I^{a, b} (mL/kg per minute)	sER^a-c (percentage)	mDO₂I^b (mm Hg/kg per minute)	Mesent lac (mmol/L)	Arterial Hb^b (g/L)	Arterial pH	Arterial pO₂ (mm Hg)	Arterial pCO₂ (mm Hg)	Arterial BE (mmol/L)
Restricted Ringer lactate solution (R-RL)
0 minutes	109 ± 11	49 ± 5	25 ± 2	1.5 ± 0.4	101 ± 7	7.51 ± 0.02	138 ± 9	36 ± 2	5.4 ± 0.9
60 minutes	103 ± 11	48 ± 6	26 ± 2	1.4 ± 0.6	102 ± 6	7.51 ± 0.02	135 ± 10	36 ± 3	5.3 ± 1.2
180 minutes	97 ± 12	50 ± 6	21 ± 2	1.2 ± 0.3	105 ± 9	7.5 ± 0.02	134 ± 15	36 ± 2	4.5 ± 1.7
240 minutes	97 ± 12	50 ± 4	20 ± 1	1.3 ± 0.2	104 ± 6	7.49 ± 0.04	135 ± 12	37 ± 2	4.3 ± 2.0
Goal-directed Ringer lactate solution (GD-RL)
0 minutes	109 ± 17	51 ± 4	26 ± 6	1.4 ± 0.2	100 ± 10	7.52 ± 0.05	132 ± 11	37 ± 3	6.3 ± 1.9
60 minutes	116 ± 19	50 ± 4	30 ± 8	1.2 ± 0.2	99 ± 10	7.52 ± 0.04	132 ± 10	36 ± 2	6.4 ± 2.0
180 minutes	134 ± 26	44 ± 4	27 ± 6	1.2 ± 0.3	96 ± 6	7.49 ± 0.037	127 ± 10	38 ± 2	5.6 ± 2.0
240 minutes	130 ± 18	42 ± 7	26 ± 7	1.2 ± 0.3	90 ± 8	49 ± 0.03	126 ± 9	38 ± 3	5.1 ± 2.1
Goal-directed colloid solution (GD-C)
0 minutes	116 ± 18	50 ± 6	26 ± 6	1.4 ± 0.4	97 ± 12	7.52 ± 0.03	135 ± 12	37 ± 3	5.8 ± 1.2
60 minutes	141 ± 22^c	38 ± 5^{b, c}	35 ± 8	0.9 ± 0.2	86 ± 10	7.5 ± 0.02	132 ± 17	38 ± 3	5.7 ± 1.4
180 minutes	151 ± 33^d	38 ± 4^{d, e}	29 ± 6^d	0.8 ± 0.3	89 ± 11^d	7.49 ± 0.02	131 ± 14	38 ± 1	5.0 ± 1.3
240 minutes	158 ± 38^d	37 ± 5^d	27 ± 5^d	0.8 ± 0.3	87 ± 12^d	7.49 ± 0.02	128 ± 16	37 ± 1	4.6 ± 1.0

Data are presented as mean ± standard deviation. t = 0 baseline values are from before the start of the respective fluid therapy. The measurements were performed hourly for 4 hours. Significant differences (P < 0.05) for area under the curve: ^aR-RL versus GD-RL, ^bR-RL versus GD-C, ^cGD-RL versus GD-C. Significant differences (P < 0.05) for analysis of variance for repeated measurements (Tukey post hoc test): ^dR-RL versus GD-C, ^eGD-RL versus GD-C. The R-RL group received 3 mL/kg per hour of lactated Ringer solution throughout the entire experiment. The GD-RL group received 3 mL/kg per hour of lactated Ringer solution plus 250 mL of lactated Ringer solution if SvO₂ was less than 60%. The GD-C group received 3 mL/kg per hour of lactated Ringer solution plus 250 mL of hydroxyethyl starch (130/0.4) if SvO₂ was less than 60%. BE, standard base excess; Hb, hemoglobin concentration; mDO₂I, mesenteric oxygen delivery; mesent lac, mesenteric venous lactate; pCO₂, carbon dioxide partial pressure; pO₂, oxygen partial pressure; sDO₂, systemic oxygen delivery index; sER, systemic oxygen extraction ratio.

ISSN: 1364-8535