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Table 1 Parameter estimates used in the model

From: Cost effectiveness of antimicrobial catheters in the intensive care unit: addressing uncertainty in the decision

Parameters Baseline estimate Variation (SEM) Distribution Source Level of evidence
Infection-related events:
   Probability of CR-BSI Modeled in stepwise incrementsa Beta Database 1
   RR mortality (CR-BSI) 1.06 0.18 Log normal [1] 2
   Extra days in the ICU 2.41 0.83 Log normal [22] 2
   Extra days on hospital ward 7.54 1.81 Log normal   
Effectiveness A-CVCs (RR):
   SPC 0.54 0.62 Log transformed normal [21] 1 +
   CH/SSD (ext) 0.66 0.17    
   CH/SSD (int/ext) 0.70 0.43    
   MR 0.39 0.43    
Baseline probabilities of mortality:
   ICU mortality 0.098 0.002 Beta Dataset 2
   Hospital mortality 0.069 0.001 Beta Dataset 2
   Annual mortality post discharge Year 1 0.050 0.002 Beta [24] 2
  Years 2 to 3 0.027 0.002    
  Years 4 to 5 0.028 0.002    
  Years 6 to 10 0.037 0.003    
  Years 11 to 15 0.042 0.003    
   Underlying annual mortality 45 to 64 years 0.004 - NA [25] 1
  65 to 84 years 0.030 -    
  85 + years 0.140 -    
Utilities:
   Utility ICU 0.66 0.27 Beta [28] 3
   Utilities population norms 50 to 59 years 0.80 0.22 Beta [27] 3
  60 to 69 years 0.79 0.19    
  70 to 79 years 0.75 0.25    
  80 + years 0.66 0.29    
Costs, 2006 AUD:
   ICU bed day 3,021 - NA [31] 4
   Hospital bed day 843 - NA [32] 3
   Diagnostics CR-BSI 101.70 - NA Database 1
   Treatment CR-BSI 591.30 - NA Database 1
   Additional cost per catheter SPC 22.36 - NA Database 1
  CH/SSD (ext) 11.64 -    
  CH/SSD (int/ext) 41.35 -    
  MR 59.36 -    
  1. aAvailable on request from the authors.
  2. A-CVCs, antimicrobial central venous catheters; CH/SSD, chlorhexidine silver sulfadiazine; CR-BSI, catheter related bloodstream infection; ICU, intensive care unit; int/ext, internally and externally coated; MR, minocycline and rifampicin; RR, relative risk; SPC, silver, platinum and carbon.