Heikki Savolainen, Dept. of Occup. Safety & Hlth., Tampere, Finland
20 February 2009
The increased susceptibility to generalized infections in diabetes can be compared with the increased risk for active tuberculosis in the same patients (1).
As to the mechanism, it may be suggested that the downstream metabolites of the excessive glucose concentration are toxic to the immunological regulatory system. The principal intermediate methylglyoxal downregulates the Raf-1 thereby attenuating the system (2).
An idea of the circulating methylglyoxal concentration can be had by the urinalysis for D-lactic acid, its eventual metabolite (3).
1 Murray JCY. Diabetes mellitus increases the risk of active tuberculosis. A systematic review of 13 observational studies. PLoS Med 2008; 5: e152.
2 Du J, Zen J, Ou X, et al. Methylglyoxal downregulates Raf-1 protein through a ubiquination-mediated mechanism. In J Biochem Cell Biol 2006; 38: 1084
3 Talasniemi JP, Pennanen S, Savolainen H, et al. Assay of D-lactate in diabetic plasma and urine. Clin Biochem 2008; 41: 1099
Critical Care
Infection susceptibility in diabetes
20 February 2009
The increased susceptibility to generalized infections in diabetes can be compared with the increased risk for active tuberculosis in the same patients (1).
As to the mechanism, it may be suggested that the downstream metabolites of the excessive glucose concentration are toxic to the immunological regulatory system. The principal intermediate methylglyoxal downregulates the Raf-1 thereby attenuating the system (2).
An idea of the circulating methylglyoxal concentration can be had by the urinalysis for D-lactic acid, its eventual metabolite (3).
1 Murray JCY. Diabetes mellitus increases the risk of active tuberculosis. A systematic review of 13 observational studies. PLoS Med 2008; 5: e152.
2 Du J, Zen J, Ou X, et al. Methylglyoxal downregulates Raf-1 protein through a ubiquination-mediated mechanism. In J Biochem Cell Biol 2006; 38: 1084
3 Talasniemi JP, Pennanen S, Savolainen H, et al. Assay of D-lactate in diabetic plasma and urine. Clin Biochem 2008; 41: 1099
Competing interests
None