Figure 2
From: Central sympatholytics prolong survival in experimental sepsis
Clonidine attenuates cytokine response after caecal ligation and puncture (CLP)-induced sepsis. Mice in the verum group (n = 10) received clonidine (5 μg/kg) 12 hours and 1 hour before CLP, as well as 1 hour, 6 hours and 12 hours after CLP. The control group (n = 10) received injections with solvent respectively. (a) Pre-emptive administration of clonidine decreases mIL-1β levels after CLP induced sepsis. Experimental sepsis led to a profound increase in mIL-1β in mouse serum 24 hours after CLP. This increase was significantly attenuated by pre-emptive clonidine injections (p = 0.017) as described above. (b) Pre-emptive administration of clonidine decreases mIL-6 levels after CLP induced sepsis. Experimental sepsis led to a profound increase in mIL-6 in mouse serum 24 hours after CLP. This increase was significantly attenuated by pre-emptive clonidine injections (p < 0.0001) as described above. (c) Pre-emptive administration of clonidine decreases mTNF-α levels after CLP-induced sepsis. Experimental sepsis led to a profound increase in TNF-α in mouse serum 24 hours after CLP. This increase was significantly attenuated by pre-emptive clonidine injections (p < 0.0001) as described above. * indicates statistical significant differences between the groups.