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Inhibition of inducible nitric oxide synthase (iNOS) reduces multi-organ failure (MOF) in the thioacetamide (TAA) rat model
Critical Care volume 4, Article number: P49 (2000)
The role of iNOS in MOF has been controversial, studies having presented contradicting results, however, the use of more specific inhibitors of iNOS may provide benefit.
To examine the effects of iNOS inhibition in our model of TAA induced MOF.
MOF was induced by two intraperitoneal (IP) injections of TAA (500 mg/kg) eight hours apart. Three groups were studied, Group 1 receiving TAA only. Group 2 and 3 followed thr protocol for Group 1, however, Group 2 was pre-treated with the NO precursor L-Arginine (300 mg/kg IP) once daily and Group 3 was pre-treated with NO synthase inhibitor aminoguanidine (100 mg/kg SC) for three days.
See Table. n=10 Mean ± SD.
The histological sections show markedly less organ damage in the aminoguanidine group (Group 3).
Inhibition of iNOS using aminoguanidine significantly improves the incidence of MOF and mortality in the TAA model of MOF.
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Rahman, T., Hodgson, H. Inhibition of inducible nitric oxide synthase (iNOS) reduces multi-organ failure (MOF) in the thioacetamide (TAA) rat model. Crit Care 4, P49 (2000). https://doi.org/10.1186/cc769
- Nitric Oxide
- Emergency Medicine
- Specific Inhibitor
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- Histological Section