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Assessment of IL-18 values in septic acute lung injury/acute respiratory distress syndrome patients

Introduction

IL-18 is said to be involved in organ injury. We investigated the IL-18 values of septic acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) patients.

Methods

The subjects were 38 patients during the 3-year period from 2004 to 2007 from whom it was possible to collect a blood specimen within approximately 6 hours of the onset of septic ALI or ARDS. Their mean age was 67 years, and their mean APACHE II score was 29. Their Sequential Organ Failure Assessment score was 13, and their mean PaO2/FiO2 ratio was 170. The PaO2/FiO2 ratio was 246 in the ALI group and 135 in the ARDS group. There were four cases (10.5%) in the 28-day mortality group, and six cases (15.8%) in the 90-day mortality group.

Results

The value of IL-18 in the dead group was significantly higher than in the surviving group (1,649 ± 1,056 pg/ml vs. 4,523 ± 2,798 pg/ml; P < 0.05), and in the ARDS group was also significantly higher than in the ALI group (2,467 ± 1,880 pg/ml vs. 1,314 ± 800 pg/ml; P < 0.05).

Conclusion

These results suggested that IL-18 may play a major role in progression of ARDS in respiratory disorder as multiple organ failure.

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Kikkawa, T., Suzuki, Y., Makabe, H. et al. Assessment of IL-18 values in septic acute lung injury/acute respiratory distress syndrome patients. Crit Care 13, P368 (2009). https://doi.org/10.1186/cc7532

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Keywords

  • Public Health
  • Emergency Medicine
  • Respiratory Disorder
  • Organ Failure
  • Acute Lung Injury