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Effect of intravenous administration of freeze-dried sulfonated human normal immunoglobulin for septic patients

Introduction

The proinflammatory cytokine TNF plays a critical role in the formation of severe sepsis when it is excessively released. Recently, it was revealed through our animal models that intravenous administration of freeze-dried sulfonated human normal immunoglobulin (IVIG) makes anti-inflammatory effects by enhancing insulin-like growth factor 1 (IGF-1) production through stimulation of sensory nerves, which inhibits the production of TNF. In this study, we examined whether IVIG for septic patients enhances IGF-1 production.

Methods

Fourteen septic patients indicating a high level of soluble E-selectin were surveyed, who were transported to our hospital from April to November 2007. They were divided into two groups, IVIG group (G-group, 5 g/day × 3 days, nine cases, 67.2 ± 8.64 years old) and nonadministered group (control group, C-group, five cases, 69 ± 12.9 years old).

Results

In the G-group, the values of IGF-1 on the fifth day (162.22 ± 52.91 ng/ml) and seventh day (150.44 ± 29.06 ng/ml) were significantly higher than that on day 0 (88.59 ± 29.79 ng/ml, P < 0.05). Furthermore, The value of IGF-1 of the G-group (162.22 ± 52.91 ng/ml) was significantly higher than that of the C-group (68.80 ± 24.04 ng/ml) on the fifth day (P < 0.05).

Conclusion

We revealed that IVIG for septic patients enhances IGF-1 production. Furthermore we will enhance the effect of sulfanated immunoglobulin compared with that of intact immunoglobulin in the difference of the anti-inflammatory effect and the mechanism.

References

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    Okajima K, Harada N, Suga H, Nakagawa T: Rapid assay for plasma soluble E-selectin predicts the development of acute respiratory distress syndrome in patients with systemic inflammatory response syndrome. Transl Res 2006, 148: 295-300. 10.1016/j.trsl.2006.07.009

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    Harada N, Okajima K, Kurihara H, Nakagata N: Antithrombin prevents reperfusion-induced hepatic apoptosis by enhancing insulin-like growth factor-I production in mice. Crit Care Med 2008, 36: 971-974. 10.1097/CCM.0B013E3181653642

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Deguchi, Y., Nakagawa, T., Suga, H. et al. Effect of intravenous administration of freeze-dried sulfonated human normal immunoglobulin for septic patients. Crit Care 13, P322 (2009). https://doi.org/10.1186/cc7486

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Keywords

  • Public Health
  • Sulfanated
  • Growth Factor
  • Sulfonated
  • Animal Model