Volume 13 Supplement 1

29th International Symposium on Intensive Care and Emergency Medicine

Open Access

RIFLE classification can predict hospital mortality of critically ill patients

  • HY Xu1,
  • JM Peng1,
  • ZR Mao2,
  • L Weng1,
  • XY Hu1 and
  • B Du1
Critical Care200913(Suppl 1):P264

https://doi.org/10.1186/cc7428

Published: 13 March 2009

Introduction

The Acute Dialysis Quality Initiative group has proposed the RIFLE (Risk–Injury–Failure–Loss–End-stage renal disease) classification to assess acute kidney injury (AKI). We sought to evaluate the incidence of AKI in critically ill patients according to the RIFLE classification and the correlation between RIFLE class and hospital mortality.

Methods

We performed a retrospective cohort study applying the RIFLE classification on 1,138 patients admitted to the ICU during a 2-year period.

Results

According to the RIFLE classification, 376 patients (33%) had AKI during their ICU stay. When assessing the maximum RIFLE class, 209 (18.3%) patients were classified Risk, 63 (5.5%) as Injury and 104 (6.3%) as Failure. Female (OR = 1.53; 95% CI = 1.18 to 1.98; P = 0.001), nonsurgical admission (OR = 1.32; 95% CI = 1.01 to 1.70; P = 0.039), APACHE II on admission above 25 (OR = 1.99; 95% CI = 1.06 to 3.76; P = 0.033), sepsis on admission (OR = 2.20; 95% CI = 1.01 to 4.79; P = 0.046) and chronic organ dysfunction (OR = 1.65; 95% CI = 1.09 to 2.50; P = 0.017) were independent risk factors for AKI. Patients with progressive RIFLE classification had increased hospital mortality, with Risk 13.9%, Injury 22.2% and Failure 47%, as compared with 7.9% (P < 0.001) among patients without AKI. Furthermore, the RIFLE class Failure was an independent predictor of 3-month hospital mortality (OR = 2.37; 95% CI = 1.23 to 4.54; P = 0.009) in addition to organ failure on admission (OR = 4.60; 95% CI = 2.31 to 9.18; P < 0.001), use of vasopressor (OR = 2.34; 95% CI = 1.09 to 5.00; P = 0.028), and APACHE II score on admission (OR = 1.160; 95% CI = 1.11 to 1.21; P < 0.001).

Conclusion

Patients with increasing RIFLE classification had significant elevated hospital mortality. Maximum RIFLE class Failure was independently associated with 3-month hospital mortality.

Authors’ Affiliations

(1)
Peking Union Medical College Hospital
(2)
First Affiliated Hospital of Henan College of Traditional Chinese Medicine

References

  1. Bellomo R, et al.: Acute renal failure-definitions, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8: R204-R212. 10.1186/cc2872PubMed CentralView ArticleGoogle Scholar
  2. Hoste EA, et al.: RIFLE criteria for acute kidney injury are associated with hospital mortality in critical ill patients: a cohort analysis. Crit Care 2006, 10: R73-R83. 10.1186/cc4915PubMed CentralView ArticleGoogle Scholar

Copyright

© Xu et al; licensee BioMed Central Ltd. 2009

This article is published under license to BioMed Central Ltd.

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