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Table 4 Clotting and haematological parameters during and post-DrotAA infusion.

From: Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy

Variable

DrotAA median (IQR)

Post-DrotAA Median (IQR)

p-value

HbMax (g/dL)

10.1 (9.57 to 11.0)

9.45 (8.9 to 10.3)

< 0.01*

HbMin, (g/dL)

8.7 (8.1 to 9.3)

8.3 (7.4 to 9.1)

0.1

PLTMax,

104 (64 to 177)

110 (85 to 166)

0.8

PLTMin

88 (41 to 164)

99 (60 to 160)

0.8

FibrinogenMax

5.1 (3.8 to 6.7)

4.4 (3.1 to 6.0)

0.07

FibrinogenMin

4.85 (3.4 to 6.1)

4.4 (3.2 to 6.0)

0.3

INRMax

1.43 (1.3 to 1.7)

1.3 (1.2 to 1.8)

0.047*

INRMin

1.3 (1.2 to 1.5)

1.3 (1.1 to 1.6)

0.8

APTTMax, s

57 (48.6 to 69.2)

43.8 (37 to 62)

< 0.01*

APTTMin, s

51 (43.2 to 59)

44 (37 to 62)

0.05

  1. Data are expressed as maximum and minimum median values (interquartile range).
  2. APTT = activated partial thromboplastin time; DrotAA = drotrecogin alfa (activated), Hb = haemoglobin, INR = international normalized ratio; PLT = platelets.