Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial

Table 3 Global oxygen transport variables and acid-base balance of study patients

	Baseline	12 hours	P value
Oxygen delivery index (ml/min/m²)			0.951
Phenylephrine	500 ± 205	498 ± 177
Norepinephrine	499 ± 139	506 ± 140
Oxygen consumption index (ml/min/m²)			0.568
Phenylephrine	164 ± 48	150 ± 41
Norepinephrine	173 ± 53	161 ± 58
Oxygen extraction ratio (%)			0.816
Phenylephrine	34 ± 9	32 ± 8
Norepinephrine	36 ± 11	32 ± 10*
Hemoglobin (g/dl)			0.699
Phenylephrine	8.4 ± 0.9	8.4 ± 1.1
Norepinephrine	8.3 ± 0.7	8.4 ± 0.6
pHa (-log₁₀c(H⁺))			0.435
Phenylephrine	7.37 ± 0.07	7.37 ± 0.08
Norepinephrine	7.35 ± 0.09	7.34 ± 0.08
Arterial base excess (mmol/l)			0.228
Phenylephrine	-0.2 ± 5.8	0.2 ± 6.3
Norepinephrine	-2.4 ± 6.6	-3.0 ± 6.4
Arterial carbon dioxide partial pressure (mmHg)			0.346
Phenylephrine	44 ± 10	44 ± 10
Norepinephrine	41 ± 6	41 ± 6
Arterial oxygen partial pressure (mmHg)			0.963
Phenylephrine	128 ± 36	119 ± 31
Norepinephrine	121 ± 24	120 ± 26
Arterial oxygen saturation (%)			0.912
Phenylephrine	98 ± 2	98 ± 2
Norepinephrine	98 ± 1	98 ± 2
Mixed venous oxygen saturation (%)			0.431
Phenylephrine	66 ± 9	67 ± 9
Norepinephrine	64 ± 11	67 ± 10
P_aO₂/FiO₂			0.971
Phenylephrine	229 ± 103	208 ± 89
Norepinephrine	222 ± 75	218 ± 71

P_aO₂/FiO₂, ratio of arterial oxygen partial pressure and inspiratory oxygen fraction (Horovitz index). *P < 0.05 versus baseline (significant time effect).

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