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Table 2 Multivariable regression analysis of factors associated with the involvement of MDR pathogens in VAP (n = 192).

From: Determinants and impact of multidrug antibiotic resistance in pathogens causing ventilator-associated-pneumonia

Predictor

Parameter estimate

OR

CI

p value

Enter method

    

Age

0.01

1.01

0.99 to 1.03

0.23

Charlson index

0.85

1.09

0.93 to 1.27

0.28

Coma on ICU admission

-0.83

0.44

0.19 to 1.03

0.06

ARDS before VAP

0.52

1.69

0.86 to 3.31

0.13

RRT before VAP

-0.42

0.66

0.31 to 1.42

0.29

Duration of hospitalisation before VAP

0.006

1.01

1.00 to 1.02

0.20

One antibiotic before VAP

0.06

1.06

0.39 to 2.92

0.90

Two antibiotic classes before VAP

0.85

2.34

0.82 to 6.71

0.11

More than two antibiotic classes before VAP

1.37

3.93

1.26 to 12.23

0.02

Constant

-2.72

   

Backward stepwise

    

Coma on ICU admission

-1.12

0.32

0.14 to 0.73

0.01

Two antibiotic classes before VAP

0.88

2.41

1.22 to 4.79

0.01

More than two antibiotic classes before VAP

1.50

4.47

2.15 to 9.31

< 0.001

Constant

-1.50

   
  1. Overall correct prediction: 77%.
  2. Hosmer-Lemeshow goodness-of-fit: Chi-square 4.74, p = 0.8, eight degrees of freedom. ROC curve: area under the curve = 0.80 (0.73 to 0.86).
  3. ARDS = acute respiratory distress syndrome; CI = confidence interval; ICU = intensive care unit; MDR = multidrug resistant; OR = odds ratio; RRT = renal replacement therapy; VAP = ventilator-associated pneumonia.