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Table 2 Airway pressures, respiratory system mechanics, and heart rate before and up to 12 hours after salmeterol administration

From: Duration of salmeterol-induced bronchodilation in mechanically ventilated chronic obstructive pulmonary disease patients: a prospective clinical study

 

Baseline

15 minutes

30 minutes

1 hour

2 hours

3 hours

4 hours

6 hours

8 hours

10 hours

12 hours

Ppk

35.0 ± 5.1

33.0 ± 5.1a

31.4 ± 5.0a

30.8 ± 4.8a

30.6 ± 4.9a

30.4 ± 4.9a

30.6 ± 4.5a

30.7 ± 4.6a

31.4 ± 4.5a

32.3 ± 4.5a

33.2 ± 4.5a

P1

22.3 ± 4.1

21.4 ± 4.3a

20.7 ± 4.4a

20.5 ± 4.2a

20.4 ± 4.4a

20.2 ± 4.1a

20.3 ± 3.8a

20.4 ± 3.9a

20.5 ± 3.6a

20.9 ± 3.7a

21.4 ± 3.7a

P2

16.7 ± 3.1

15.8 ± 2.8a

15.3 ± 3.1a

15.1 ± 2.9a

15.0 ± 3.1a

14.9 ± 3.2a

14.9 ± 2.8a

15.0 ± 2.8a

15.2 ± 2.7a

15.5 ± 2.6a

16.0 ± 2.7

PEEPi

7.1 ± 1.6

6.2 ± 1.7a

5.5 ± 1.9a

5.2 ± 1.8a

5.2 ± 1.8a

5.1 ± 1.8a

5.1 ± 1.8a

5.2 ± 1.9a

5.4 ± 1.8a

5.7 ± 1.8a

6.2 ± 1.8a

Rrs

25.4 ± 4.1

23.8 ± 4.4a

22.3 ± 4.1a

21.7 ± 3.6a

21.6 ± 3.6a

21.5 ± 3.5a

21.8 ± 3.3a

21.6 ± 3.6a

22.5 ± 4.2a

23.2 ± 4.1a

23.9 ± 3.8a

Rint

17.6 ± 3.7

16.1 ± 4.0a

14.9 ± 3.6a

14.3 ± 3.1a

14.2 ± 3.0a

14.2 ± 3.0a

14.3 ± 3.0a

14.3 ± 3.0a

15.1 ± 3.7a

16.0 ± 3.9a

16.4 ± 3.4a

ΔR

7.7 ± 2.2

7.7 ± 2.5

7.5 ± 2.2

7.5 ± 2.2

7.5 ± 2.2

7.3 ± 1.9

7.5 ± 1.9

7.3 ± 2.0

7.3 ± 2.0

7.2 ± 2.0

7.5 ± 2.1

Cst, rs

54.3 ± 9.0

54.2 ± 9.0

53.1 ± 7.4

52.3 ± 7.4

53.0 ± 7.4

53.3 ± 7.5

53.1 ± 7.7

52.7 ± 6.7

52.8 ± 6.3

52.2 ± 5.8

52.2 ± 5.8

HR

74.8 ± 8.5

75.0 ± 7.3

74.5 ± 6.8

75.0 ± 7.2

74.5 ± 6.2

73.9 ± 7.7

73.5 ± 8.7

73.1 ± 9.6

73.8 ± 8.8

74.8 ± 11.0

73.4 ± 10.2

  1. Values are presented as mean ± standard deviation. aSignificantly different from baseline values (P < 0.05, Wilcoxon signed rank test). bRespiratory system mechanics were measured while the patients were on volume control with square wave inspiratory flow-time profile. Crs, st, end-inspiratory static compliance of the respiratory system (mL/cm H2O); HR, heart rate (beats per minute); P1, airway pressure at the point of zero flow (cm H2O); P2, plateau pressure (cm H2O); PEEPi, intrinsic positive end-expiratory pressure (cm H2O); Ppk, peak airway pressure (cm H2O); Rint, minimum inspiratory resistance (cm H2O/L per second); Rrs, maximum inspiratory resistance (cm H2O/L per second); ΔR, difference between maximum inspiratory resistance and minimum inspiratory resistance (cm H2O/L per second).