Table 3 The effect of AKI on the activity of selected rat model CYP enzymes
From: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury
Rat CYP | Effect | AKI model |
|---|---|---|
2A1 | ↔ | Uranyl nitrate induced kidney injury |
2B1/2 | ↔ | Uranyl nitrate induced kidney injury |
2C6 | ↔ | Nephrectomy |
|  | ↔ | Bilateral ureteral ligation |
|  | ↔ | Glycerol-induced kidney injury |
|  | ↓ | Cisplatin-induced kidney injury |
2C11 | ↓ | Uranyl nitrate induced kidney injury |
2D2 | ↔ | Nephrectomy |
|  | ↔ | Bilateral ureteral ligation |
|  | ↔ | Glycerol-induced kidney injury |
|  | ↔ | Cisplatin-induced kidney injury |
2E1 | ↑ | Uranyl nitrate induced kidney injury |
3A1 (3A23) | ↑ | Uranyl nitrate induced kidney injury |
3A2 | ↓ | Nephrectomy |
|  | ↔ | Bilateral ureteral ligation |
|  | ↓ | Glycerol-induced kidney injury |
|  | ↔ | Cisplatin-induced kidney injury |