Table 2 Animal studies investigating the effect of AKI on hepatic drug metabolism
From: Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury
Drug | Animal | AKI model | Authors' conclusion on effect of AKI on hepatic metabolism |
|---|---|---|---|
Ajmaline [18] | Rat | Uranyl nitrate | ↔ |
Clarithromycin [26] | Rat | Uranyl nitrate | ↔ |
Cyclosporine [21] | Rat | Gentamicin | ↔ |
Diltiazem [70] | Rat | Uranyl nitrate | ↑ |
Diltiazem [71] | Rabbit | Folate | ↓ |
Etoposide [72] | Rat | Uranyl nitrate | ↔ |
Losartan [19] | Rat | Uranyl nitrate and bilateral ureter ligation | ↔ |
Metoprolol [22] | Rat | Bilateral ureteral ligation | ↔ |
Metoprolol [23] | Rat | Glycerol | ↔ |
Propranolol [20] | Rat | Cisplatin | ↔ |
Propranolol [22] | Rat | Bilateral ureteral ligation | ↔ |
Tacrolimus [73] | Rat | Cisplatin | ↓ |
Telithromycin [27] | Rat | Uranyl nitrate | ↔ |
Theophylline [74] | Rat | Uranyl nitrate | ↑ |