Acute kidney injury is common, parallels organ dysfunction or failure, and carries appreciable mortality in patients with major burns: a prospective exploratory cohort study

Table 5 Early and late acute kidney injury: odds ratio for characteristics, multiple organ failure, and sepsis

	Early AKI	Late AKI
Failure/Injury/Risk (all patients)	3/5/9 (17)	3/5/6 (14)	95% CI	OR
Age of <60/≥60 years	13/4	5/9	1.22 to 28.0	5.85
TBSA% of ≥50%/<50%	10/7	3/11	1.06 to 26.0	5.20
FTB% of ≥25%/<25%	12/5	4/10	1.26 to 28.5	6.00
Gender, male/female	12/5	9/5	0.29 to 6.04	1.33
Mortality (non-survivors)	6	5	0.22 to 4.30	0.98
Dialysis	3	1	0.26 to 30.27	2.79
MOF before AKI	13	10	0.26 to 6.52	1.30
Sepsis before AKI	11	8^a	0.32 to 5.88	1.38
MOF and sepsis both before AKI	8	8	0.16 to 2.77	0.67
MAP episode <60 mm Hg on days 1–3	10	9	0.18 to 3.41	0.79
Adrenergic drugs on days 1–3	14	7	0.91 to 23.79	4.67

Data are number of patients. Early acute kidney injury (AKI) is defined as when creatinine reached the level for Risk within the first 7 days; late AKI occurred between days 8 and 60. Multiple organ failure (MOF) is defined as 3 to 4 score points in two or more organ dimensions of the sequential organ failure assessment score. Onset on the same day as AKI is included in the onset before category. ^aTwo more patients had sepsis before AKI, but there were 11 and 48 days, respectively, between their sepsis recordings and AKI onset, which was on days 25 and 60. Continuous variables were arbitrarily categorised: cutoff for age was 60 years, full thickness burn percentage (FTB%) was 25%, and percentage burned of total body surface area (TBSA%) was 50%. CI, confidence interval; MAP, mean arterial pressure; OR, odds ratio.

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