Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital

Table 3 Clotting screen test results: mean PT and APTT before and after administration of PCC

Clotting parameter		Cardiac surgery (CABG)	Cardiac surgery (valve replacement)	Other surgery	Warfarin reversal	All patients
PT	Pre-PCC	19.1	24.0	32.9	52.7	35.9
	Post-PCC	15.7	13.8	15.7	14.7	15.2
	Percentage change	-17.8%	-42.5%	-52.3%	-72.1%	-57.7%
APTT	Pre-PCC	113.4	146.1	97.3	39.4	100.8
	Post-PCC	73.3	82.6	78.2	29.8	65.3
	Percentage change	-35.4%	-43.5%	-19.6%	-24.4%	-35.2%

APTT data were incomplete for one patient in the 'other surgery' group and for six patients in the warfarin reversal group, and so these patients were excluded from the analyses. APTT, activated partial thromboplastin time; CABG, coronary artery bypass graft; PCC, prothrombin complex concentrate; PT, prothrombin time.

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