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Figure 6 | Critical Care

Figure 6

From: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

Figure 6

High-molecular-weight hyaluronan (1,600 kDa) given after lipopolysaccharide infusion blocked neutrophil infiltration in a dose-dependent manner. Animals were infused with 0.025%, 0.05%, or 0.1% high-molecular-weight hyaluronan (HMW HA) or 0.1% sodium carboxymethyl cellulose (CMC) at 500 μl/hour starting 1 hour after lipopolysaccharide (LPS) (3 mg/kg) infusion. Intravenous HMW HA given post LPS infusion showed a dose-dependent decrease in neutrophil infiltration, which was only partially explained by charge – as evidenced by significantly less inhibition with 0.1% CMC, a positively charged carbohydrate of similar molecular weight, as compared with 0.1% HMW HA. *P < 0.05 versus LPS, #P < 0.05 versus LPS + 0.1% HMW HA. BAL, bronchoalveolar lavage.

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Critical Care

ISSN: 1364-8535