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Figure 2 | Critical Care

Figure 2

From: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

Figure 2

Only high-molecular-weight hyaluronan (1,600 kDa) decreased lung injury on pathology. Animals were pretreated with either 1,600 kDa or 35 kDa hyaluronan 18 hours prior to ventilation. Lipopolysaccharide (LPS) (1 mg/kg) was given by arterial injection 1 hour prior to the start of ventilation. After 4 hours of ventilation, animals were sacrificed and the left lung was fixed with formaldehyde, sliced and stained with hematoxylin and eosin. LPS caused edema and inflammatory cell infiltration, which was decreased with high-molecular-weight hyaluronan pretreatment. Non-vent, nonventilated.

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Critical Care

ISSN: 1364-8535