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Figure 1 | Critical Care

Figure 1

From: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

Figure 1

Only high-molecular-weight hyaluronan (1,600 kDa) completely blocked both lung neutrophil and monocyte infiltration. Animals were pretreated with either 1,600 kDa or 35 kDa hyaluronan 18 hours prior to ventilation. Lipopolysaccharide (LPS) (1 mg/kg) was given by arterial injection 1 hour prior to the start of ventilation. After 4 hours of ventilation, animals were sacrificed and the left lung was lavaged. (a) Neutrophils × 10,000/ml bronchoalveolar lavage fluid (BAL). (b) Monocytes × 10,000/ml BAL. (c) Myeloperoxidase assay optical density (MPO OD)/mg lung tissue. *P < 0.01 versus control, #P < 0.01 versus with LPS. Non-vent, nonventilated.

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Critical Care

ISSN: 1364-8535