Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study

Haase, Michael; Bellomo, Rinaldo; Story, David; Davenport, Piers; Haase-Fielitz, Anja

doi:10.1186/cc6972

Critical Care

Table 3 Performance characteristics of urinary interleukin-18 (IL-18) according to different renal outcome definitions

From: Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study

Variables	AUC-ROCC (95% CI)	P value
Increase in serum creatinine > 25% within 24 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.58 (0.46–0.71)	0.19
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.56 (0.43–0.69)	0.34
Increase in serum creatinine > 50% within 24 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.56 (0.38–0.74)	0.51
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.57 (0.40–0.73)	0.45
Increase in serum creatinine > 25% within 48 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.59 (0.47–0.71)	0.14
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.56 (0.43–0.68)	0.36
Increase in serum creatinine > 50% within 48 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.53 (0.38–0.68)	0.70
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.55 (0.40–0.71)	0.48
Increase in serum creatinine > 25% within 72 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.60 (0.39–0.71)	0.63
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.58 (0.44–0.72)	0.55
Increase in serum creatinine > 50% within 72 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.58 (0.36–0.66)	0.85
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.55 (0.41–0.69)	0.50
Increase in serum creatinine > 25% within 120 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.60 (0.48–0.72)	0.10
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.59 (0.47–0.71)	0.14
Increase in serum creatinine > 50% within 120 hours postoperatively
Urinary IL-18 on arrival in the intensive care unit	0.52 (0.38–0.67)	0.78
Urinary IL-18 at 24 hours after cardiopulmonary bypass	0.56 (0.43–0.70)	0.38

AUC-ROCC, area under the curve for the receiver operating characteristic curve; CI, confidence interval.

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