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Table 3 Performance characteristics of urinary interleukin-18 (IL-18) according to different renal outcome definitions

From: Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: a prospective observational cohort study

Variables AUC-ROCC (95% CI) P value
Increase in serum creatinine > 25% within 24 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.58 (0.46–0.71) 0.19
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.56 (0.43–0.69) 0.34
Increase in serum creatinine > 50% within 24 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.56 (0.38–0.74) 0.51
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.57 (0.40–0.73) 0.45
Increase in serum creatinine > 25% within 48 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.59 (0.47–0.71) 0.14
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.56 (0.43–0.68) 0.36
Increase in serum creatinine > 50% within 48 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.53 (0.38–0.68) 0.70
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.55 (0.40–0.71) 0.48
Increase in serum creatinine > 25% within 72 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.60 (0.39–0.71) 0.63
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.58 (0.44–0.72) 0.55
Increase in serum creatinine > 50% within 72 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.58 (0.36–0.66) 0.85
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.55 (0.41–0.69) 0.50
Increase in serum creatinine > 25% within 120 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.60 (0.48–0.72) 0.10
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.59 (0.47–0.71) 0.14
Increase in serum creatinine > 50% within 120 hours postoperatively   
   Urinary IL-18 on arrival in the intensive care unit 0.52 (0.38–0.67) 0.78
   Urinary IL-18 at 24 hours after cardiopulmonary bypass 0.56 (0.43–0.70) 0.38
  1. AUC-ROCC, area under the curve for the receiver operating characteristic curve; CI, confidence interval.