Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome

Table 1 Time course of haemodynamic parameters, inspiratory plateau airway pressure, arterial blood pH, PaO₂ and PaCO₂ after oleic acid injection and during a decremental PEEP trial from 20 to 0 cm H₂O.

	HR (beats/min)	Mean AP (mmHg)	pH	PaO₂ (mmHg)	PaCO₂ (mmHg)	Inspiratory plateau pressure (cm H₂O)
ARDS	129 ± 3	75 ± 16	7.32 ± 0.06	52 ± 5	54 ± 5	20 ± 1
ARDS20	132 ± 4	66 ± 13	7.33 ± 0.04	172 ± 15*	54 ± 3	36 ± 3*
ARDS15	134 ± 4	73 ± 13	7.38 ± 0.02	175 ± 17*	54 ± 2	26 ± 1*
ARDS10	145 ± 3*	75 ± 9	7.28 ± 0.05	89 ± 19*	56 ± 5	23 ± 2
ARDS5	165 ± 10*	118 ± 9*	7.33 ± 0.02	52 ± 4*	59 ± 2	22 ± 2
ARDS0	153 ± 7*	101 ± 5*	7.3 ± 0.03	52 ± 4*	62 ± 3*	21 ± 2

Data are presented as mean ± standard error of the mean. Measurements were obtained 120 min after oleic acid injection at a PEEP of 5 cm H₂O (ARDS) and during a decremential PEEP trial (ARDS20, ARDS15, ARDS10, ARDS5, ARDS0). Each PEEP level was maintained for 15 min before each measurement to allow for haemodynamic and respiratory stabilisation. ARDS, acute respiratory distress syndrome; HR, heart rate; mean AP, mean systemic arterial pressure; PEEP, positive end-expiratory pressure. * p < 0.05 versus ARDS

ISSN: 1364-8535